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商品描述
| Kitsize | 30 |
| Method | RIA |
| Incubationtime | 1x3h,1x1h |
| Standardrange | negativeandpositivecontrol |
| Specimen/Volumes | 20µLserum |
| Substrate/isotope | 125I<50kBq |
| RegulatoryStatus: | EU:CE |
Detailsfor:AcetylcholineReceptor-Ab(ARAb)BlockingRIA
IBL我们的液体处理专业知识可实现高度复杂的分子诊断技术的可靠自动化，例如细胞遗传学（核型分析和FISH）和分子细胞遗传学（aCGH /阵列比较基因组杂交），其应用范围从代谢疾病和癌症到生殖遗传学和移植药物。该产品组合涵盖了细胞遗传学和分子细胞遗传学工作流程的关键阶段，从标准化工作站，经过验证的应用程序和专用用户界面，到与Tecan Labwerx合作开发的高度定制的平台。 RADIoimmunoassayforthequantitativedeterminationofblockingautoantibodiesagainsttheacetylcholinereceptorinhumanserum.TheARAbBlockingRIAisusefulasanaidinthedifferentialdiagnosisofmyastheniagravis(MG).Myastheniagravis(MG)isanacquireddisorderofneuromusculartransmissionassociatedwithabnormalmuscleweaknessandfatigABIlitiesonexertion.Thismuscleweaknessincreaseswithmuscleactivity,eventuallyreachingastateofpseudoparalysis.Aftermusclerelaxationthemotilityisrestored.Musclesthatarerequiredforbodyposture,includingfacialandneckmusclesaswellasocularmusclesandmusclesneededforspeakingandswallowingaremostaffected.Clinicalsymptomsmayberestrictedtoonemusclegroup,inparticulartheeyemuscles(ocularMG)orbecomegeneralized(generalizedMG).Myastheniagraviscanoccurfromearlychildhoodtooldageanditsprevalenceisabout5per100,000.Inwomen,thediseaseusuallypresentsbetweentheagesof20to40,whereasinmentheageofpresentationtendstobebetween40and60years.TheincidenceofMGis40to60newcasespermillionpeopleperyear.AutoantibodiesdirectedagainstacetylcholinereceptorsalongthepostsynapticmembraneareresponsIBLeforthemuscleweaknessandfatigabilitiesinMG.ThreefunctionallydifferenttypesofantibodiesagainstacetylcholinereceptorsaredetectableinpatientswithMG:receptorbinding,blockingandmodulatingantibodies.Relatedtotheblockingantibodiesthereisasignificantcorrelationbetweenthedegreeofacetylcholinereceptorblockadeandgeneralizationofmuscleweakness.Therefore,measurementofblockingacetylcholinereceptorautoantibodiesisofadditionalvalueindifferentialdiagnosisofMG.
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