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苏州工业园区生物纳米园A4#216
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4000-520-616 / 18915418616
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商品描述
| Kitsize | 100 |
| Method | RIA(DAK) |
| Incubationtime | 1x20h |
| Standardrange | 0.05-15pmol/mLacetylation,1.5-450pmol/mLwithoutacetylation |
| Specimen/Volumes | 20µLacetyl.plasma,urine,cellandtissuesUSPension |
| Substrate/isotope | 125I≤150kBq |
| RegulatoryStatus: | EU:CE,CDN:IVD |
Detailsfor:cAMPRIA
IBL我们的液体处理专业知识可实现高度复杂的分子诊断技术的可靠自动化，例如细胞遗传学（核型分析和FISH）和分子细胞遗传学（aCGH /阵列比较基因组杂交），其应用范围从代谢疾病和癌症到生殖遗传学和移植药物。该产品组合涵盖了细胞遗传学和分子细胞遗传学工作流程的关键阶段，从标准化工作站，经过验证的应用程序和专用用户界面，到与Tecan Labwerx合作开发的高度定制的平台。 RADIoimmunoassayforthein-vitrodiagnosticquantitativedeterminationofcAMPinhumanplasmaandurine.Thetestcanalsobeusedfornon-clinicalapplicationsinotherBIOLOGicalmaterial.Cyclicadenosin-3",5"-monophosphate(cAMP)servesasasecondmessengerinsignaltransductionofvarioushormones,likeadrenaline,ACTH,LH,FSH,glucagonandcalcitonin.Thehormoneitselfisthefirstmessenger,bindingtospecificmembranereceptorsofhormone-responsivecells.Thisleadstotheactivationofanenzymelocatedattheinnersideofthecellmembrane,calledadenylatecyclase,whichcatalysesthesynthesisofcAMPfromATP.TheincreasedcellularlevelofcAMPinitiatestheactivationofproteinkinases.
ThedeterminationofcAMPinurine(orplasma)hasbecomemoreandmoreimportantintheclinicalassessmentofparathyroidfunctions.Theparathyroidhormone(PTH)stimulatesthesynthesisofcAMPintherenalcortexandanincreasedsecretionofcAMP.ThenephrogeniccAMPisaspecificMarkerofcirculatingPTH:90%ofpatientswithhyperparathyroidismshowincreasedlevelsofnephrogeniccAMP.ThedeterminationofnephrogeniccAMPisalsosignificantforthedifferentialdiagnosisofhypercalcemia.
UrinarylevelsofcAMPsupportthediagnosisofhypoparathyroidismandpseudohypoparathyroidism:TheadmiNISTrationofPTHtopatientswithpseudohypoparathyroidismdoesnotleadtoanincreasedcAMPsecretion,whichisindicativeofadefectiveadenylatecyclaseintherenalcortex.
TotalurinarycAMPlevelscomprisethenephrogeniccAMPandtheplasmacAMPwhichisnotresorbedinthekidneys.InmostcasesthedeterminationoftotalurinarycAMPissufficient,becausetheconcentrationofplasmaticcAMPismoreorlessconstant.
ForconcretedatapleaseconsulttheInstructionforUseinthedownloadboxontherightside.ThedeterminationofcAMPinurine(orplasma)hasbecomemoreandmoreimportantintheclinicalassessmentofparathyroidfunctions.Theparathyroidhormone(PTH)stimulatesthesynthesisofcAMPintherenalcortexandanincreasedsecretionofcAMP.ThenephrogeniccAMPisaspecificMarkerofcirculatingPTH:90%ofpatientswithhyperparathyroidismshowincreasedlevelsofnephrogeniccAMP.ThedeterminationofnephrogeniccAMPisalsosignificantforthedifferentialdiagnosisofhypercalcemia.
UrinarylevelsofcAMPsupportthediagnosisofhypoparathyroidismandpseudohypoparathyroidism:TheadmiNISTrationofPTHtopatientswithpseudohypoparathyroidismdoesnotleadtoanincreasedcAMPsecretion,whichisindicativeofadefectiveadenylatecyclaseintherenalcortex.
TotalurinarycAMPlevelscomprisethenephrogeniccAMPandtheplasmacAMPwhichisnotresorbedinthekidneys.InmostcasesthedeterminationoftotalurinarycAMPissufficient,becausetheconcentrationofplasmaticcAMPismoreorlessconstant.
