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苏州工业园区生物纳米园A4#216
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商品描述
| Kitsize | 12x8 |
| Method | LuminescenceImmunoassay |
| Incubationtime | 1x4h,1x10min |
| Standardrange | 10-1000pg/mL |
| Specimen/Volumes | 20µLsaliva/withoutextraction |
| Substrate/isotope | Acridiumbased |
| RegulatoryStatus: | EU:CE,CDN:IVD |
Detailsfor:ProgesteroneSalivaLuminescenceImmunoassay
IBL我们的液体处理专业知识可实现高度复杂的分子诊断技术的可靠自动化，例如细胞遗传学（核型分析和FISH）和分子细胞遗传学（aCGH /阵列比较基因组杂交），其应用范围从代谢疾病和癌症到生殖遗传学和移植药物。该产品组合涵盖了细胞遗传学和分子细胞遗传学工作流程的关键阶段，从标准化工作站，经过验证的应用程序和专用用户界面，到与Tecan Labwerx合作开发的高度定制的平台。 Luminescenceimmunoassayforthein-vitro-diagnosticquantitativedeterminationofactivefreeprogesterone(afemalehormone)inhumansaliva.Measurementsobtainedbythisdevicemaybeusedinthediagnosisandtreatmentofdisordersoftheovariesandcanbeusedasanaidforconfirmationofovulation.
Progesterone,aC21-steroid,isafemalesexhormoneandaprecursorinthemetabolismofothersteroids.Progesteroneissynthesizedmainlyinthecorpusluteumoftheovaries,duringthemainpartofpregnancyintheplacentaandinverysmallamountsfortheproductionofothersteroidsintheadrenalcortexandinthetestes.Atthelatterlocationsprogesteroneisimportantforthesynthesisofaldosterone,cortisol,testosteroneand17-b-estrADIol.
Inthecirculationthemainpartofprogesteroneisboundtothecorticoidbindingglobulin(CBG,Transcortin),tothesexhormonebindingglobulin(SHBG)andtoalbumin.1–2%ofprogesteronecirculatesasafreehormoneinplasma.Onlythisportionrepresentstheactivepartintheendocrineregulation.Thefreehormoneisreleasedinequalamountsinsaliva.Anenzymaticmetabolizationofportionsofthishormoneinthesalivaglandsispresumed.
Progesteroneisoneimportanthormoneoftheendocrineregulationofthemenstrualcycle.Afterovulationprogesteroneissecretedbythecorpusluteumwhichdevelopsfromtheovulatedfollicleintheovaries.Theprogesteronelevelrisesinthe6th–8thdayafterovulationtoaplateau.TogetherwithestradiolitinhibitsthereleaseofLHandFSHinthepituitaryglandbyanegativefeedbackmechanism.Progesteroneissecretedintothecirculationinapulsatingway.Becauseofthelysisofthecorpusluteum,theprogesteroneleveldecreasesinthelast3daysofthecycletoapre-ovulatorylevel.
Inpregnancy,beginningatthe8thgestationweek,theplacentabecomesthemajorsourceofprogesteroneproductionduringthe2ndand3rdtrimester.
Thecourseofprogesteronelevelsinthecirculationisreflectedinitsconcentrationinsaliva.Themostimportanttaskofprogesteroneistopreparethegenitalorgansofthewomenforapotentialimplantationandtomaintainthepregnancy.Themaineffectsofprogesteronearetointroducethesecretoryphaseoftheendometrium,tosuppressthecontractionsoftheuterusandtostimulatethegrowthofmammarytissue,aswellasothereffectsonthemetabolismandtheendocrinesysteminwomen.
Regardingphysiology,themeasurementofprogesteroneinsalivaisusefulinmonitoringthemenstrualcycleinwomeninordertodeterminethetimeofovulationandtoassessthefunctionofthecorpusluteum,whichbecomesimportantintheearlystagesofpregnancy.Becausethefluctuationsoftheprogesteronelevelsdependsalsoonindividualsituations,itisveryconvenienttogetahormoneprofilebyrepeatedlycollectingsalivasamples.
ForconcretedatapleaseconsulttheInstructionforUseinthedownloadboxontherightside.Progesterone,aC21-steroid,isafemalesexhormoneandaprecursorinthemetabolismofothersteroids.Progesteroneissynthesizedmainlyinthecorpusluteumoftheovaries,duringthemainpartofpregnancyintheplacentaandinverysmallamountsfortheproductionofothersteroidsintheadrenalcortexandinthetestes.Atthelatterlocationsprogesteroneisimportantforthesynthesisofaldosterone,cortisol,testosteroneand17-b-estrADIol.
Inthecirculationthemainpartofprogesteroneisboundtothecorticoidbindingglobulin(CBG,Transcortin),tothesexhormonebindingglobulin(SHBG)andtoalbumin.1–2%ofprogesteronecirculatesasafreehormoneinplasma.Onlythisportionrepresentstheactivepartintheendocrineregulation.Thefreehormoneisreleasedinequalamountsinsaliva.Anenzymaticmetabolizationofportionsofthishormoneinthesalivaglandsispresumed.
Progesteroneisoneimportanthormoneoftheendocrineregulationofthemenstrualcycle.Afterovulationprogesteroneissecretedbythecorpusluteumwhichdevelopsfromtheovulatedfollicleintheovaries.Theprogesteronelevelrisesinthe6th–8thdayafterovulationtoaplateau.TogetherwithestradiolitinhibitsthereleaseofLHandFSHinthepituitaryglandbyanegativefeedbackmechanism.Progesteroneissecretedintothecirculationinapulsatingway.Becauseofthelysisofthecorpusluteum,theprogesteroneleveldecreasesinthelast3daysofthecycletoapre-ovulatorylevel.
Inpregnancy,beginningatthe8thgestationweek,theplacentabecomesthemajorsourceofprogesteroneproductionduringthe2ndand3rdtrimester.
Thecourseofprogesteronelevelsinthecirculationisreflectedinitsconcentrationinsaliva.Themostimportanttaskofprogesteroneistopreparethegenitalorgansofthewomenforapotentialimplantationandtomaintainthepregnancy.Themaineffectsofprogesteronearetointroducethesecretoryphaseoftheendometrium,tosuppressthecontractionsoftheuterusandtostimulatethegrowthofmammarytissue,aswellasothereffectsonthemetabolismandtheendocrinesysteminwomen.
Regardingphysiology,themeasurementofprogesteroneinsalivaisusefulinmonitoringthemenstrualcycleinwomeninordertodeterminethetimeofovulationandtoassessthefunctionofthecorpusluteum,whichbecomesimportantintheearlystagesofpregnancy.Becausethefluctuationsoftheprogesteronelevelsdependsalsoonindividualsituations,itisveryconvenienttogetahormoneprofilebyrepeatedlycollectingsalivasamples.
