Alternative Names(E,E)-1,7-bis(4-Hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione Diferuloylmethane DiferulylmethaneDescriptionCurcumin is a yellow-orange dye obtained from tumeric, the powdered root of Curcuma longa; it is employed in the preparation of curcuma paper, the detection of boron, and possesses a vast number of biological targets. Curcumin has been shown to inhibit NF-κB (possibly thru inhibition of JNK; IC50=10 μM), blocks amyloid peptide induced expression of: TNF-α, IL-1β, MCP-1, IL-8, and CCR5, regulates NOS2, inhibits IgE and Ag-induced degranulation of mast cells, inhibits 5-LO (5-lipoxygenase; IC50=8 μM), Cox-2 (cyclooxygenase-2; IC50=52 μM), the COP9 signalosome kinase (IC50=10 µM), and p300/CBP. This wide range of activities makes Curcumin an extremely useful tool for developing novel analogous molecules and discovering new uses for this naturally occurring compound.CAS Number458-37-7Chemical FormulaC₂₁H₂₀O₆Molecular Weight368.38Size1 g

Purity≥95%SolubilitySoluble in water, ethanol (10 mg/ml), DMSO (25 mg/ml) and acetic acidStorage Temp-20°C

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