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商品描述
| Description | |
|---|---|
| CatalogueNumber | MAB2130 |
| BrandFamily | Chemicon® |
| TradeName |
|
| Description | Anti-ICAM-1Antibody,cloneW-CAM-1 |
| AlternateNames |
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| ProductInformation | |
|---|---|
| Format | Ascites |
| Control |
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| Presentation | Liquidcontainingsodiumazide. |
| StorageandShippingInformation | |
|---|---|
| StorageConditions | Maintainat-20°Cinundilutedaliquotsforuptooneyear.Avoidrepeatedfreeze/thawcycles. |
| BIOLOGicalInformation | |
|---|---|
| Immunogen | RAJIcells |
| Clone | W-CAM-1 |
| Host | Mouse |
| Specificity | ICAM-1belongstotheimmunoglobulinsuperfamily,C2subset.Itisatransmembranemoleculeof90kDwith7potentialN-glycosylationsites.Itisexpressedonrestingmonocytesandendothelialcellsandcanbeupregulatedonmanyothercells,e.g.withlymphokines,onBandTlymphocytes,thymocytes,dendriticcells,keratinocytes,chondrocytes,andepithelialcells.CD54mediatescelladhesionbindingtointegrinsCD11a/CD18(LFA-1)andtoCD11b/CD18(Mac-1).TheinteractionofCD54withLFA-1enhancesantigen-specificTcellactivation.CD54alsobindstoCD43andtoPlasmodiumfalciparum-infectederythrocytes. |
| Isotype | IgG |
| SpeciesReactivity |
|
| SpeciesReactivityNote | Demonstratedtoreactwithratmesenchymalstemcells. |
| AntibodyType | MonoclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | ICAM1(CD54)istypicallyexpressedonendothelialcellsandcellsoftheimmunesystem.ICAM1bindstointegrinsoftypeCD11a/CD18,orCD11b/CD18.ICAM1isalsoexploitedbyRhinovirusasareceptor. |
| GeneSymbol |
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| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:P05362#ICAMproteinsareligandsfortheleukocyteadhesionproteinLFA-1(integrinalpha-L/beta-2).Incaseofrhinovirusinfectionactsasacellularreceptorforthevirus.Alsoactsasreceptorforsomecoxsackieviruses. SIZE:532aminoacids;57825Da SUBUNIT:Interactswithhumanherpesvirus8MIR2protein(Probable). SUBCELLULARLOCATION:Membrane;Single-passtypeImembraneprotein. PTM:Monoubiquitinated,whichispromotedbyMARCH9andleadstoendocytosis. SIMILARITY:SwissProt:P05362##Belongstotheimmunoglobulinsuperfamily.ICAMfamily.&Contains5Ig-likeC2-type(immunoglobulin-like)domains. |
| PhysicochemicalInformation |
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| Dimensions |
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| MaterialsInformation |
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| MaterialsInformation |
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