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商品描述
Description | |
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CatalogueNumber | MAB2130 |
BrandFamily | Chemicon® |
TradeName |
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Description | Anti-ICAM-1Antibody,cloneW-CAM-1 |
AlternateNames |
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ProductInformation | |
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Format | Ascites |
Control |
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Presentation | Liquidcontainingsodiumazide. |
StorageandShippingInformation | |
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StorageConditions | Maintainat-20°Cinundilutedaliquotsforuptooneyear.Avoidrepeatedfreeze/thawcycles. |
BIOLOGicalInformation | |
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Immunogen | RAJIcells |
Clone | W-CAM-1 |
Host | Mouse |
Specificity | ICAM-1belongstotheimmunoglobulinsuperfamily,C2subset.Itisatransmembranemoleculeof90kDwith7potentialN-glycosylationsites.Itisexpressedonrestingmonocytesandendothelialcellsandcanbeupregulatedonmanyothercells,e.g.withlymphokines,onBandTlymphocytes,thymocytes,dendriticcells,keratinocytes,chondrocytes,andepithelialcells.CD54mediatescelladhesionbindingtointegrinsCD11a/CD18(LFA-1)andtoCD11b/CD18(Mac-1).TheinteractionofCD54withLFA-1enhancesantigen-specificTcellactivation.CD54alsobindstoCD43andtoPlasmodiumfalciparum-infectederythrocytes. |
Isotype | IgG |
SpeciesReactivity |
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SpeciesReactivityNote | Demonstratedtoreactwithratmesenchymalstemcells. |
AntibodyType | MonoclonalAntibody |
EntrezGeneNumber | |
EntrezGeneSummary | ICAM1(CD54)istypicallyexpressedonendothelialcellsandcellsoftheimmunesystem.ICAM1bindstointegrinsoftypeCD11a/CD18,orCD11b/CD18.ICAM1isalsoexploitedbyRhinovirusasareceptor. |
GeneSymbol |
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UniProtNumber | |
UniProtSummary | FUNCTION:SwissProt:P05362#ICAMproteinsareligandsfortheleukocyteadhesionproteinLFA-1(integrinalpha-L/beta-2).Incaseofrhinovirusinfectionactsasacellularreceptorforthevirus.Alsoactsasreceptorforsomecoxsackieviruses. SIZE:532aminoacids;57825Da SUBUNIT:Interactswithhumanherpesvirus8MIR2protein(Probable). SUBCELLULARLOCATION:Membrane;Single-passtypeImembraneprotein. PTM:Monoubiquitinated,whichispromotedbyMARCH9andleadstoendocytosis. SIMILARITY:SwissProt:P05362##Belongstotheimmunoglobulinsuperfamily.ICAMfamily.&Contains5Ig-likeC2-type(immunoglobulin-like)domains. |
PhysicochemicalInformation |
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MaterialsInformation |
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MaterialsInformation |
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