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蚂蚁淘在线 / 品牌中心 / Millipore / Millipore/FCMAB168P | Milli-Mark Anti-CD3 -PE Antibody, clone UCHT1/FCMAB168P/100 tests
商品描述
Description | |
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CatalogueNumber | FCMAB168P |
TradeName |
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Description | Milli-MarkAnti-CD3-PEAntibody,cloneUCHT1 |
AlternateNames |
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BackgroundInformation | HumanTCR/CD3isacomplexstructureonthelymphocytesurface.ItconsistsoftheTCRalphabetaorTCRgammadeltaheterodimerandtheassociatedCD3complex.TheCD3complexiscomposedofsixpolypeptideswithusuallyfourdifferenttransmembraneCD3chains,gamma,delta,epsilon.andzeta.Threedifferentdimers,gammaepsilon,deltaepsilon,andzetazeta,constitutetheCD3complex.TheMWofCD3epsilonis20000(Campana,1987).CD3isfirstdetectableinearlythymocytesanditsappearanceprobablyrepresentsoneoftheearliestsignsofcommitmenttotheTcelllineage.Incorticalthymocytes,duringearlystagesofmaturation,theCD3antigenispredominantlypresentinthecellcytoplasm.Inmedullarythymocyles,theCD3antigenispredominantlydetectedonthecellsurface(Swerdlow,1988;Beverley,1981).ThemajorityofTcellneoplasmsalsoexpressesCD3,butitisabsentfromnon-T-celllymphoidmalignancies(McMichael,1987).Consistentwiththepatternofsynthesisoftheantigeninnormalthymocytes,theearliestsitedetectablewithinneoplasticcellsisthecellcytoplasm(Swerdlow,1988). |
ProductInformation | |
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Format | Phycoerythrin |
Control |
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Presentation | PurifiedMousemonoclonalIgG1conjugatedtoPEin0.05MTris-HClbufferwith1%BSA,SodiumAzideat0.097%atpH7.2 |
StorageandShippingInformation | |
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StorageConditions | Maintainrefrigeratedat2-8°Cprotectedfromlightinundilutedaliquotsforupto6monthsfromdateofreceipt. |
Applications | |
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Application | Milli-MarkAnti-CD3-PEAntibody,cloneUCHT1isanantibodyagainstCD3foruseinFC. |
KeyApplications |
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BIOLOGicalInformation | |
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Immunogen | HumaninfantthymocytesandlymphocytesfromapatientwithSézarydisease. |
Clone | UCHT1 |
Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
Host | Mouse |
Specificity | AntibodyrecognizesHumanCD3antigen. |
Isotype | IgG1κ |
SpeciesReactivity |
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AntibodyType | MonoclonalAntibody |
EntrezGeneNumber | |
PurificationMethod | ProteinAPurfied |
UniProtNumber | |
MolecularWeight | 20kDa(Campana,1987) |
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Dimensions |
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MaterialsInformation |
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MaterialsInformation |
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