Catalogue numbercrb1200274Antigen Peptideβ-actin peptideProtein IDUniProtKB - P60709AliasesACTB, BRWS1, PS1TP5BP1, Beta-actin, β actin, β-actin, βactinCross-ReactivityHuman, Rat, MouseDisease AreaCell motility, structure and integrityFamilyActinStorage -20°CReferences

Dugina, V., Khromova, N., Rybko, V., Blizniukov, O., Shagieva, G., Chaponnier, C., Kopnin, B. and Kopnin, P. (2015). Tumor promotion by γ and suppression by β non-muscle actin isoforms. Oncotarget, 6(16). PMID: 26008973

Discovery Antibodies的Cyclin dependant kinase 2 (CDK2) is a serine/threonine protein kinase which controls both G1/S and G2/M transitions. CDKs along with cyclins and CDK inhibitors regulate cell cycle progression. Specific cyclins activate different CDKs; in early G1, CDK2 pairs with cyclin E to promote entry into the S phase before switching to partner with cyclin A to drive the cell through S phase. Once activated CDKs phosphorylate downstream proteins to initiate signalling cascades. CDK2 phosphorylates and inactivates the RB1 (pRb) tumour suppressor family of proteins.CDK的活动受到严格控制。CDK2活性可以被包括P21在内的一系列抑制剂抑制。细胞周期失调和增殖控制的丧失与细胞转化和癌症密切相关。CDK2在DNA损伤反应（DDR）中的细胞周期停滞中也似乎起着积极作用，它的抑制作用会阻碍DDR，并使细胞对电离辐射敏感，从而诱导细胞死亡。该抗体与AlexaFluor®488偶联。AlexaFluor®488是一种流行的鲜绿色荧光染料，具有高pH稳定性。