Catalogue numbercrb1200405AntibodyAnti-RAF1 antibodyAntigen PeptideRAF1 peptideProtein IDUniProtKB - P04049AliasesRaf-1 Proto-Oncogene, Serine/Threonine Kinase, Oncogene RAF1, CRAF, C-Raf Cross-ReactivityHumanStorage -20°CReferences

Buscaino, A., White, S., Houston, D., Lejeune, E., Simmer, F., de Lima Alves, F., Diyora, P., Urano, T., Bayne, E., Rappsilber, J. and Allshire, R. (2012). Raf1 Is a DCAF for the Rik1 DDB1-Like Protein and Has Separable Roles in siRNA Generation and Chromatin Modification. PLoS Genetics, 8(2), e1002499. PMID: 22319459

SpecificityProtein Discovery Antibodies的Cyclin dependant kinase 2 (CDK2) is a serine/threonine protein kinase which controls both G1/S and G2/M transitions. CDKs along with cyclins and CDK inhibitors regulate cell cycle progression. Specific cyclins activate different CDKs; in early G1, CDK2 pairs with cyclin E to promote entry into the S phase before switching to partner with cyclin A to drive the cell through S phase. Once activated CDKs phosphorylate downstream proteins to initiate signalling cascades. CDK2 phosphorylates and inactivates the RB1 (pRb) tumour suppressor family of proteins.CDK的活动受到严格控制。CDK2活性可以被包括P21在内的一系列抑制剂抑制。细胞周期失调和增殖控制的丧失与细胞转化和癌症密切相关。CDK2在DNA损伤反应（DDR）中的细胞周期停滞中也似乎起着积极作用，它的抑制作用会阻碍DDR，并使细胞对电离辐射敏感，从而诱导细胞死亡。该抗体与AlexaFluor®488偶联。AlexaFluor®488是一种流行的鲜绿色荧光染料，具有高pH稳定性。