Catalogue numbercrb1200271Antigen PeptidePhospho-NR2A (pS1232) peptideProtein IDUniProtKB - Q00959 Rat,P35436 Mouse ,Q12879 HumanAliasesGRIN2A, GluN2A, NMDAR2A, NR2A, EIEE27, glutamate ionotropic receptor NMDA type subunit 2A/ NMDA NR2A SubunitCross-ReactivityRat, Mouse, HumanDisease AreaNeurodegenerativeFamilyGlutamate-gated ion channel family Post-translational ModificationPhosphorylation of Serine 1232Storage -20°CReferences

Dong, L., Chen, J., Li, F., Gao, F., Wu, J., Miao, Y. and Wang, Z. (2013). Enhanced Expression of NR2B Subunits of NMDA Receptors in the Inherited Glaucomatous DBA/2J Mouse Retina. Neural Plast, 2013, 1-7. PMID: 24175101

Li, B., Sun, M., Zhang, L., Takahashi, S., Ma, W., Vinade, L., Kulkarni, A., Brady, R. and Pant, H. (2001). Regulation of NMDA receptors by cyclin-dependent kinase-5. PNAS, 98(22), 12742-12747. PMID: 11675505

Discovery Antibodies的Cyclin dependant kinase 2 (CDK2) is a serine/threonine protein kinase which controls both G1/S and G2/M transitions. CDKs along with cyclins and CDK inhibitors regulate cell cycle progression. Specific cyclins activate different CDKs; in early G1, CDK2 pairs with cyclin E to promote entry into the S phase before switching to partner with cyclin A to drive the cell through S phase. Once activated CDKs phosphorylate downstream proteins to initiate signalling cascades. CDK2 phosphorylates and inactivates the RB1 (pRb) tumour suppressor family of proteins.CDK的活动受到严格控制。CDK2活性可以被包括P21在内的一系列抑制剂抑制。细胞周期失调和增殖控制的丧失与细胞转化和癌症密切相关。CDK2在DNA损伤反应（DDR）中的细胞周期停滞中也似乎起着积极作用，它的抑制作用会阻碍DDR，并使细胞对电离辐射敏感，从而诱导细胞死亡。该抗体与AlexaFluor®488偶联。AlexaFluor®488是一种流行的鲜绿色荧光染料，具有高pH稳定性。