Catalogue numbercrb1200371AntibodyAnti-FGFR2c antibodyAntigen PeptideFGFR2c peptideAliasesFibroblast growth factor receptor 2c, FGFR2cCross-ReactivityHumanStorage -20°CReferences

Pfaff, M., Xue, K., Li, L., Horowitz, M., Steinbacher, D. and Eswarakumar, J. (2016). FGFR2c-mediated ERK–MAPK activity regulates coronal suture development. Dev Biol, 415(2), 242-250. PMID: 27034231

Ranieri, D., Rosato, B., Nanni, M., Belleudi, F. and Torrisi, M. (2017). Expression of the FGFR2c mesenchymal splicing variant in human keratinocytes inhibits differentiation and promotes invasion. Mol Carcinog, 57(2), 272-283. PMID: 29068468

SpecificityProtein Discovery Antibodies的Cyclin dependant kinase 2 (CDK2) is a serine/threonine protein kinase which controls both G1/S and G2/M transitions. CDKs along with cyclins and CDK inhibitors regulate cell cycle progression. Specific cyclins activate different CDKs; in early G1, CDK2 pairs with cyclin E to promote entry into the S phase before switching to partner with cyclin A to drive the cell through S phase. Once activated CDKs phosphorylate downstream proteins to initiate signalling cascades. CDK2 phosphorylates and inactivates the RB1 (pRb) tumour suppressor family of proteins.CDK的活动受到严格控制。CDK2活性可以被包括P21在内的一系列抑制剂抑制。细胞周期失调和增殖控制的丧失与细胞转化和癌症密切相关。CDK2在DNA损伤反应（DDR）中的细胞周期停滞中也似乎起着积极作用，它的抑制作用会阻碍DDR，并使细胞对电离辐射敏感，从而诱导细胞死亡。该抗体与AlexaFluor®488偶联。AlexaFluor®488是一种流行的鲜绿色荧光染料，具有高pH稳定性。