Catalogue number	crb2005277
Antibody	Anti-WT1 antibody
Antigen Peptide	KLH conjugated synthetic peptide crb1200511e
Protein ID	UniProtKB - Q1L884
Aliases	WT1 transcription factor, Wilms tumor suppressor protein 1b
Cross-Reactivity	Danio rerio (Zebrafish)
Host Species	Rabbit
Antibody Type	Polyclonal
Concentration	3mg/ml
Validation	1:1000 (ELISA), 1:25000 (IHC)
Target	Wt1a and Wt1b
Disease Area	Tumour, tissue regeneration
Storage	This material is supplied in PBS containing 0.01% sodium azide and 1% trehalose. The product should be stored at +4°C for short term storage and -20°C for long term storage. Avoid repeated freeze/ thaw cycles.
Citations	Lopez-Baez et al(2018). Wilms Tumor 1b defines a wound-specific sheath cell subpopulation associated with notochord repair. Elife. pii: e30657.PMID: 29405914
References	Perner et al., (2007). The Wilms tumor geneswt1aandwt1bcontrol different steps during formation of the zebrafish pronephros. Dev. Biol. 309(1): 87. PMID:17651719 Hastie (2017). Wilms" tumour 1 (WT1) in development, homeostasis and disease. Development. 144(16):2862. PMID:28811308

Discovery Antibodies的Cyclin dependant kinase 2 (CDK2) is a serine/threonine protein kinase which controls both G1/S and G2/M transitions. CDKs along with cyclins and CDK inhibitors regulate cell cycle progression. Specific cyclins activate different CDKs; in early G1, CDK2 pairs with cyclin E to promote entry into the S phase before switching to partner with cyclin A to drive the cell through S phase. Once activated CDKs phosphorylate downstream proteins to initiate signalling cascades. CDK2 phosphorylates and inactivates the RB1 (pRb) tumour suppressor family of proteins.CDK的活动受到严格控制。CDK2活性可以被包括P21在内的一系列抑制剂抑制。细胞周期失调和增殖控制的丧失与细胞转化和癌症密切相关。CDK2在DNA损伤反应（DDR）中的细胞周期停滞中也似乎起着积极作用，它的抑制作用会阻碍DDR，并使细胞对电离辐射敏感，从而诱导细胞死亡。该抗体与AlexaFluor®488偶联。AlexaFluor®488是一种流行的鲜绿色荧光染料，具有高pH稳定性。