Catalogue numbercrb2005268AntibodyAnti-Grip71 antibodyAntigen PeptideKLH conjugated synthetic peptide crb1200507eProtein IDUniProtKB - Q9VJ57_DROMEAliasesDGrip71, Dgp71WDCross-ReactivityDrosophila Host Species RabbitAntibody TypePolyclonalValidationWB (1:1000), ELISA (1:1000), ImmunoprecipitationTargetGrip71-PA (single isoform gene)Disease AreaCytoskeleton, Microtubles, gamma-tubulin ring complexFamilyGrip71/NEDD1/GCPWDSpecificityProtein Storage The product should be stored at -20°C for for short term storage and long term storage. Avoid repeated freeze/ thaw cycles. CitationsTovey, C., Tubman, C., Hamrud, E., Zhu, Z., Dyas, A., Butterfield, A., Fyfe, A., Johnson, E. and Conduit, P. (2018). γ-TuRC Heterogeneity Revealed by Analysis of Mozart1. Current Biology, 28(14), pp.2314-2323.e6References

Gunawardane, R., Martin, O. and Zheng, Y. (2003). Characterization of a New γTuRC Subunit with WD Repeats. Mol Biol Cell, 14(3), 1017-1026. PMID: 12631720

Romé, P. and Ohkura, H. (2018). A novel microtubule nucleation pathway for meiotic spindle assembly in oocytes. J Cell Biol, 217(10), 3431-3445. PMID: 30087124

Discovery Antibodies的Cyclin dependant kinase 2 (CDK2) is a serine/threonine protein kinase which controls both G1/S and G2/M transitions. CDKs along with cyclins and CDK inhibitors regulate cell cycle progression. Specific cyclins activate different CDKs; in early G1, CDK2 pairs with cyclin E to promote entry into the S phase before switching to partner with cyclin A to drive the cell through S phase. Once activated CDKs phosphorylate downstream proteins to initiate signalling cascades. CDK2 phosphorylates and inactivates the RB1 (pRb) tumour suppressor family of proteins.CDK的活动受到严格控制。CDK2活性可以被包括P21在内的一系列抑制剂抑制。细胞周期失调和增殖控制的丧失与细胞转化和癌症密切相关。CDK2在DNA损伤反应（DDR）中的细胞周期停滞中也似乎起着积极作用，它的抑制作用会阻碍DDR，并使细胞对电离辐射敏感，从而诱导细胞死亡。该抗体与AlexaFluor®488偶联。AlexaFluor®488是一种流行的鲜绿色荧光染料，具有高pH稳定性。