Catalogue numbercrb2005018AntibodyAnti-Cache Valley Virus (CVV) Nucleocapsid antibodyAntigen PeptideKLH conjugated synthetic peptide crb1200003eProtein IDUniProtKB - D6MXQ7Cross-ReactivityCache Valley Virus, Batai virusHost Species RabbitAntibody TypePolyclonalConcentration1mg/mlValidationWB/ELISATargetCache Valley Virus SpecificityProteinStorage This material is supplied in PBS containing 0.01% sodium azide and 1% trehalose. The product should be stored at +4°C for short term storage and -20°C for long term storage. Avoid repeated freeze/ thaw cycles.References

Wilson, M., Suan, D., Duggins, A., Schubert, R., Khan, L., Sample, H., Zorn, K., Rodrigues Hoffman, A., Blick, A., Shingde, M. and DeRisi, J. (2017). A novel cause of chronic viral meningoencephalitis: Cache Valley virus. Ann Neurol, 82(1), 105-114. PMID: 28628941

Rodrigues Hoffmann, A., Dorniak, P., Filant, J., Dunlap, K., Bazer, F., de la Concha-Bermejillo, A., Welsh, C., Varner, P. and Edwards, J. (2013). Ovine Fetal Immune Response to Cache Valley Virus Infection. J Virol, 87(10), 5586-5592. PMID: 23468505

Discovery Antibodies的Cyclin dependant kinase 2 (CDK2) is a serine/threonine protein kinase which controls both G1/S and G2/M transitions. CDKs along with cyclins and CDK inhibitors regulate cell cycle progression. Specific cyclins activate different CDKs; in early G1, CDK2 pairs with cyclin E to promote entry into the S phase before switching to partner with cyclin A to drive the cell through S phase. Once activated CDKs phosphorylate downstream proteins to initiate signalling cascades. CDK2 phosphorylates and inactivates the RB1 (pRb) tumour suppressor family of proteins.CDK的活动受到严格控制。CDK2活性可以被包括P21在内的一系列抑制剂抑制。细胞周期失调和增殖控制的丧失与细胞转化和癌症密切相关。CDK2在DNA损伤反应（DDR）中的细胞周期停滞中也似乎起着积极作用，它的抑制作用会阻碍DDR，并使细胞对电离辐射敏感，从而诱导细胞死亡。该抗体与AlexaFluor®488偶联。AlexaFluor®488是一种流行的鲜绿色荧光染料，具有高pH稳定性。