Cataloguenumbercrb2005050AntibodyAnti-KA1antibodyAntigenPeptideKLHconjugatedsyntheticpeptidecrb1200001eProteinIDUniProtKB-Q01812AliasesGlutamatereceptorionotropic,kainate4,Grik4,GluK4,KA1,GlutamatereceptorKA-1,KA-1Cross-ReactivityMouse,RatHostSpeciesRabbitAntibodyTypePolyclonalConcentration1mg/mlValidation1:500(WB),1:1000(ELISA)TargetKA1FamilyGlutamate-gatedionicchannelfamilySpecificityProteinStorageThismaterialissuppliedinPBScontaining0.01%sodiumazideand1%trehalose.Theproductshouldbestoredat+4°Cforshorttermstorageand-20°Cforlongtermstorage.Avoidrepeatedfreeze/thawcycles.References

Fernandes,H.,Catches,J.,Petralia,R.,Copits,B.,Xu,J.,Russell,T.,Swanson,G.andContractor,A.(2009).High-AffinityKainateReceptorSubunitsAreNecessaryforIonotropicbutNotMetabotropicSignaling.Neuron,63(6),818-829.PMID:19778510

Knight,H.,Walker,R.,James,R.,Porteous,D.,Muir,W.,Blackwood,D.andPickard,B.(2011).GRIK4/KA1proteinexpressioninhumanbrainandcorrelationwithbipolardisorderriskvariantstatus.AmJMedGenetB:NeuropsychiatrGenet,159B(1),21-29.PMID:22052594

Santa_Cruz_alternativesc-8917 Discovery Antibodies的Cyclin dependant kinase 2 (CDK2) is a serine/threonine protein kinase which controls both G1/S and G2/M transitions. CDKs along with cyclins and CDK inhibitors regulate cell cycle progression. Specific cyclins activate different CDKs; in early G1, CDK2 pairs with cyclin E to promote entry into the S phase before switching to partner with cyclin A to drive the cell through S phase. Once activated CDKs phosphorylate downstream proteins to initiate signalling cascades. CDK2 phosphorylates and inactivates the RB1 (pRb) tumour suppressor family of proteins.CDK的活动受到严格控制。CDK2活性可以被包括P21在内的一系列抑制剂抑制。细胞周期失调和增殖控制的丧失与细胞转化和癌症密切相关。CDK2在DNA损伤反应（DDR）中的细胞周期停滞中也似乎起着积极作用，它的抑制作用会阻碍DDR，并使细胞对电离辐射敏感，从而诱导细胞死亡。该抗体与AlexaFluor®488偶联。AlexaFluor®488是一种流行的鲜绿色荧光染料，具有高pH稳定性。