Description: C3/C3a, Human, mAb 474, immuno assay antibody

Monoclonal antibody 474 reacts with an epitope on C3a. The antibody reacts both with intact C3 as with C3a. The complement system is an important factor in innate immunity. The third complement component, C3, is central to the classical, alternative and lectin pathways of complement activation. The synthesis of C3 is tissue-specific and is modulated in response to a variety of stimulatory agents. An inherited deficiency of C3 predisposes the person to frequent assaults of bacterial infections. Proteolysis by certain enzymes results in the cleavage of C3 into C3a and C3b. C3a is a mediator of local inflammatory processes. C3a does induce smooth muscle contraction, increases vascular permeability, and causes histamine release from mast cells and basophilic leukocytes

Specifications:

Catalog number Product type Quantity Formulation Application Application Notes Use Immunogen Isotype Species Alias Positive Control Negative Control References Storage and stability Precautions Disease

HM2073-IA

Monoclonal antibodies

0.5 mg

0.5 mg of 0.2 μm filtered protein G purified antibody solution in PBS with a concentration of at least 0.5 mg/ml (exact concentration is indicated on the label).

Immuno assays, Western blot

W: diabetic serum proteins were separated on PAGE-gel and transferred to nitrocellulose

Dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50.

C3a

Mouse IgG1

Human

Complement component 3

Human serum

C3-deficient serum

1. Hartmann, H et al; Rapid quantification of C3a and C5a using a combination of chromatographic and immunoassay procedures. J Immunol Methods 1993, 166: 35 2. Stöve, S et al; Re-evaluation of the storage conditions for blood samples which are used for determination of complement activation. J Immunol Methods 1995, 182: 1 3. Li, R et al. Localized-statistical quantification of human serum proteome associated with type 2 diabetes. Plos one 2008, 3:e3224 4. Shi, L et al. Discovery and identification of potential biomarkers of pediatric acute lymphoblastic leukemia. Proteome science 2009, 7:7

Product should be stored at 4°C. Under recommended storage conditions, product is stable for one year.

For research use only. Not for use in or on humans or animals or for diagnostics. It is the responsibility of the user to comply with all local/state and Federal rules in the use of this product. Hycult Biotech is not responsible for any patent infringements that might result with the use of or derivation of this product.

Infectious diseases, Nephrology

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