Product ID G7232Cas No. 1229208-44-9Purity ≥98%

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• Product Info
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Description

GS-9973 is an imidazopyrazine inhibitor of Syk that is currently in clinical trials as a potential treatment for chronic lymphocytic leukemia (CLL). GS-9973 exhibits anticancer chemotherapeutic activity. In vitro, this compound decreases survival of CLL cells, inhibits cell growth, and disrupts chemokine signaling.

Product Info

Cas No.PurityFormulaFormula Wt.IUPAC NameSynonymAppearance

1229208-44-9

≥98%

C23H21N7O

411.46

6-(1H-Indazol-6-yl)-N-[4-(4-morpholinyl)phenyl]imidazo[1,2-a]pyrazin-8-amine

GS9973, Entospletinib

Yellow to off white powder

Shipping and Storage

Store TempShip Temp

-20°C

Ambient

Downloads

Info Sheet

G7232 Info Sheet PDF

References

Sharman J, Hawkins M, Kolibaba K, et al. An open-label phase 2 trial of entospletinib (GS-9973), a selective Syk inhibitor, in chronic lymphocytic leukemia. Blood. 2015 Feb 18. Epub ahead of print]. PMID: 25696919.

Currie KS, Kropf JE, Lee T, et al. Discovery of GS-9973, a selective and orally efficacious inhibitor of spleen tyrosine kinase. J Med Chem. 2014 May 8;57(9):3856-73. PMID: 24779514.

Burke RT, Meadows S, Loriaux MM, et al. A potential therapeutic strategy for chronic lymphocytic leukemia by combining Idelalisib and GS-9973, a novel spleen tyrosine kinase (Syk) inhibitor. Oncotarget. 2014 Feb 28;5(4):908-15. PMID: 24659719.

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