Product overview

• NamePNU 74654
• Short descriptionβ-catenin inhibitor. Wnt pathway inhibitor.
• Biological descriptionβ-catenin inhibitor (K_d = 450 nM). Blocks the interaction with T cell factor (TCF). Inhibits the Wnt/β-catenin pathway.
• Biological actionInhibitor
• Purity>99%
• Our products in actionSubmit Your Citation Now

Properties

• Chemical name2-Phenoxybenzoic acid-[(5-methyl-2-furanyl)methylene]hydrazide
• Molecular Weight320.34
• Chemical structure
• Molecular FormulaC₁₉H₁₆N₂O₃
• CAS Number113906-27-7
• PubChem identifier60119583
• SMILESCC1=CC=C(O1)C=NNC(=O)C2=CC=CC=C2OC3=CC=CC=C3

Storing and Using Your Product

• Storage instructions+4°C
• Solubility overviewsoluble in DMSO (100mM)
• ImportantThis product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

References for PNU 74654

• Characterization of differential gene expression in adrenocortical tumors harboring beta-catenin (CTNNB1) mutations.

  Durand J et al (2011)J Clin Endocrinol Metab 96(7) : E1206-11. PubMedID: 21565795

• Inhibition of protein-protein interactions: the discovery of druglike beta-catenin inhibitors by combining virtual and biophysical screening.

  Trosset JY et al (2006)Proteins 64(1) : 60-7. PubMedID: 16568448

• Reaching for high-hanging fruit in drug discovery at protein-protein interfaces.

  Wells JA et al (2007)Nature 450(7172) : 1001-9. PubMedID: 18075579

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