信号转导是分子信号从细胞外部到内部的传输。这始于配体与细胞表面受体结合，导致受体的细胞内结构域发生变化，并且这种变化引发了一系列信号事件。信号通路的成分根据刺激进行分类。刺激配体可以是激素或神经递质，是第一信使，而受体是信号转导器。一旦被激活，它们就会连接到第二信使，即在细胞内起作用以触发响应的代理。第二信使包括环 AMP、环 GMP、一氧化氮、脂质和钙。第二信使反过来激活通常是其他酶的次级效应器，并且级联继续进行。信号转导受体有四种主要类型，酶联受体，具有相关或内在的酶活性，7-TM 受体rs，与 G 蛋白偶联，激活后直接改变基因转录的核受体，以及改变构象以允许离子通过膜的配体门控离子通道。在健康的生物体中，细胞生长和分化的过程是高度控制，但在疾病状态下变得不耦合，使不受管制的信号成为癌症、炎症、动脉硬化、关节炎和神经退行性疾病等疾病的关键因素。
显示所有 4结果
5-FAM-Fz7-21[5-FAM]-LPSDDLEFWCHVMY-酰胺
查看产品epsilon – PKC抑制剂EAVSLKPTC-酸查看产品Fz7-21Ac-LPSDDLEFWCHVMY-酰胺查看产品Panx-1模拟抑制肽WRQAAFVDSY-酸查看产品 受调节的细胞死亡受调节的细胞死亡 (RCD) 是生物体内的一个过程，对于组织稳态或压力后恢复平衡至关重要。意外细胞死亡 (ACD) 是一个生物学上不受控制的过程，而 RCD 涉及严格有序的信号级联和明确定义的效应机制。 RCD 的功能是消除不必要的或潜在危险的细胞，并且可以通过从受损细胞释放物质来触发，从而提醒生物体注意潜在威胁。细胞凋亡和自噬是程序性细胞死亡的两种主要形式。细胞凋亡发生在充分的细胞损伤后，但也通常发生在发育和衰老过程中，被认为是细胞更新、细胞发育和免疫系统的重要组成部分。自噬虽然与细胞凋亡密切相关，但其特征是细胞响应饥饿或应激信号而分解大分子，被认为是分解代谢过程。 Mult细胞死亡途径已根据形态学、生化和功能方面进行了定义，包括细胞凋亡、自噬、坏死、坏死性凋亡、细胞焦亡、铁死亡、内吞细胞死亡、溶酶体依赖性细胞死亡、碱性细胞死亡、氧化细胞死亡和网状细胞死亡。损失RCD 的控制还导致人类疾病，例如癌症、神经变性、自身免疫性疾病、传染病和许多类型的癌症。
显示所有 7 个结果
[5-TAMRA]-ATIA 激动剂 [sar1、Ile4、Ile8][5-TAMRA]-[Sar]-RVYIHPI-酸查看产品 Bak BH3GQVGRQLAIIGDDINR-酸
查看产品Beclin-1TNVFNATFHIWHSGQFGT-acid查看产品Bid BH3 肽EDIIRNIARHLAQVGDSMDR-酸查看产品BIM 187fQWAVGHLL-酰胺
查看产品Bim BH3，肽IVDMRPEIWIAQELRRIGDEFNAYYARR-酸
查看产品促凋亡肽KLA促凋亡肽KLA查看产品
上海生物芯片(SBC)
上海生物芯片有限公司(Shanghai Biochip Co. Ltd)成立于2001年8月，公司由上海创业投资有限公司、中科院上海生命科学研究院等十一家在上海的国内知名大学、研究院、医院和企业共同组建而成。2003年2月，国家发展与改革委员会批准上海生物芯片有限公司负责建设和运行\"生物芯片上海国家工程研究中心”。
公司主营业务为生物芯片的技术创新与服务、产品开发、生产与销售。公司致力于生物芯片在生命科学研究、医疗保健、食品安全和药物开发等领域的应用和推广，为人类健康造福。
抢占国际生物技术制高点 全面推进国家生物芯片产业化
公司愿景(SBC Vision)：
成为国家生物芯片技术创新和产业化基地；成为国内一流、国际知名的骨干生物技术企业。
公司使命(SBC Mission)：
应用生物芯片和功能基因组核心技术及先进成果，面向现代生物医药健康市场，成为系统生物学研究技术和服务的提供者；分子诊断技术与产品的提供者；药物开发技术与产品的提供者。
公司价值(SBC Value)：
科研创新、市场导向、以人为本
SBC is one of the largest biotech companies in China established in August 2001. The company owns a vast campus of greater than 400,000 square feet (about 10 acres), with research building space of over 200,000 square feet, located at Shanghai Zhangjiang Hi-Tech Park in Pudong.SBC has received nvestments totaling $45 million USD from government grants and 10 shareholders consisting of top VC groups, universities, research institutes, hospitals, and large biopharma at Shanghai.
SBC is also the national Engineering Center for biochip design and engineering in Shanghai.With advanced biotech platforms, GLP, GCP and GMP labs, and strong teams for research, services, marketing and sales, we provide not only a series of biochips and related technical services, but also proprietary drug targets and relevant diagnostic products. SBC currently collaborates with several top ten worldwide Pharmaceutical companies and leading diagnostic products providers located in the USA, Europe and China.
SBC was founded in 2001 with total of US$50 million by Chinese government grant and 11 share holders consisting of all top academic universities, research institutes, hospitals, and famous biotech companies in Shanghai.
SBC Vision:
Our Vision is to be the world leading Biotechnology Company based on the continual pursuit of scientific and operational excellence.
SBC Mission:
Our Mission is to develop and commercializes a broad range of products and services, including biochip products, to address significant unmet needs in drug discovery research, systems biology research, clinical applications and bio-safety testing.
SBC Value:
Science innovation, Business orientation, Career development.
MaxyBio Corporation is the USA-based subsidiary of Shanghai Biochip Co. Ltd, also known as ShanghaiBio Corporation (SBC), one of the largest biotech companies in China.MaxyBio provides biopharma R&D services from biochips to drug targets,from systems biology to pharmacogenomics, and from non-clinical researches to clinical trials
With broad connections and resources in both USA and China,MaxyBio will help global Biotech,pharmaceutical and medical companies to find their best Chinese partners for research collaborations, outsourcing, and manufacturing, and distribute their new products or technology services in China market.Local office in USA, MaxyBio Corporation to handle Export/import tissue, DNA, RNA biological materials Contracts / quotation / invoice / payment Project management Local Customer support
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