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蚂蚁淘在线 / 品牌中心 / Discovery / Discovery Antibodies/Anti-Cannabinoid Receptor 1 (extracellular) Antibody/25 µl/ACR-001-25 µl

Discovery Antibodies/Anti-Cannabinoid Receptor 1 (extracellular) Antibody/25 µl/ACR-001-25 µl

价格

￥4940.00

货号：ACR-001-25µl

浏览量：123

品牌：Discovery

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商品描述

Cat#:ACR-001

AlternativeNameCB1,CB-R, CNR1,CANN6, Brain-typecannABInoidreceptor,Centralcannabinoidreceptor

LyophilizedPowder

AntigenIncl.

Type:Polyclonal

Host:Rabbit

Reactivity:h,m,r

Immunogen-+

Accession(Uniprot)NumberP20272

GeneID25248

PeptideconfirmationConfirmedbyaminoacidanalysisandmassspectrometry.

HomologyHuman-identical;mouse-15/16aminoacidresiduesidentical.

RRIDAB_2039795.

PurityAffinitypurifiedonimmobilizedantigen.

FormLyophilizedpowder.Reconstitutedantibodycontainsphosphatebufferedsaline(PBS),pH7.4,1%BSA,0.05%NaN₃.

IsotypeRabbitIgG.

StoragebeforereconstitutionTheantibodyshipsasalyophilizedpowderatroomtemperature.Uponarrival,itshouldbestoredat-20°C.

Reconstitution25μl,50μlor0.2mldoubledistilledwater(DDW),dependingonthesamplesize.

Antibodyconcentrationafterreconstitution0.7mg/ml.

StorageafterreconstitutionThereconstitutedsolutioncanbestoredat4°Cforupto1week.Forlongerperiods,smallaliquotsshouldbestoredat-20°C.Avoidmultiplefreezingandthawing.Centrifugeallantibodypreparationsbeforeuse(10000xg5min).

NegativecontrolantigenstoragebeforereconstitutionLyophilizedpowdercanbestoredintactatroomtemperaturefor2weeks.Forlongerperiods,itshouldbestoredat-20°C.

Negativecontrolantigenreconstitution100µldoubledistilledwater(DDW).

Negativecontrolantigenstorageafterreconstitution-20°C.

PreadsorptionControl1μgpeptideper1μgantibody.

StandardqualitycontrolofeachlotWesternblotanalysis.

Applications:ic,if,ih,lci,wb

Mayalsoworkin:ifc*,ip*

Westernblot-+

Immunohistochemistry-+

Livecellimaging/Immunocytochemistry-+

References

1.Brooks,J.W.andFraquhar-Smith,M.A.(2003)Br.J.Anaesth.3,175.

2.Howlett,A.C.(2002)ProstaglandinsOtherLipidMediat.68–69,619.

3.Howlett,A.C.etal.(2002)Pharmacol.Rev.54,161.

4.Rueda,D.etal.(2000)Mol.Pharmacol.58,814.

5.Sarfaraz,S.etal.(2005)CancerRes.65,1635.

6.Casanova,M.L.etal.(2003)J.Clin.Invest.111,43.

7.Cota,D.etal.(2003)Int.J.Obes.Relat.Metab.Disord.27,289.

Scientificbackground-+

LyophilizedPowderNegativeControlAntigenIncluded

Clickheretoreceivea25µlfreetrialsample!

Image&Title:

Immuno-colocalizationofproNGFandCannabinoidReceptor1inmousehippocampaldentategyrusImmunohistochemicalstainingofimmersion-fixed,freefloatingmousebrainfrozensectionsusingGuineapigAnti-proNGFAntibody (#AGP-031),(1:300)andrabbit Anti-CannabinoidReceptor1(extracellular) Antibody(#ACR-001),(1:300).A.proNGFstaining(red)appearsinthedentategyrus(DG)granulelayer(G)andinhilarinterneurons(arrows).B.CB1staining(green)appearsinaxonalprocessessurroundingthegranulelayerandafewhilarinterneurons(arrows).C.Mergeofthetwoimagesrevealsco-localizationofproNGFandCB1inafewhilarcells.CellnucleiwerestainedwithDAPI(blue).

Lastupdate:10/11/2019

Anti-CannabinoidReceptor1(extracellular)Antibody(#ACR-001)isahighlyspecificantibodydirectedagainstanepitopeoftheratCB1receptor.Theantibodycanbeusedinwesternblot,immunohistochemistry,andlivecellimagingapplications.IthasbeendesignedtorecognizeCB1inhuman,mouse,andratsamples.

Forresearchpurposesonly,notforhumanuse

Discovery Antibodies的Cyclin dependant kinase 2 (CDK2) is a serine/threonine protein kinase which controls both G1/S and G2/M transitions. CDKs along with cyclins and CDK inhibitors regulate cell cycle progression. Specific cyclins activate different CDKs; in early G1, CDK2 pairs with cyclin E to promote entry into the S phase before switching to partner with cyclin A to drive the cell through S phase. Once activated CDKs phosphorylate downstream proteins to initiate signalling cascades. CDK2 phosphorylates and inactivates the RB1 (pRb) tumour suppressor family of proteins.CDK的活动受到严格控制。CDK2活性可以被包括P21在内的一系列抑制剂抑制。细胞周期失调和增殖控制的丧失与细胞转化和癌症密切相关。CDK2在DNA损伤反应（DDR）中的细胞周期停滞中也似乎起着积极作用，它的抑制作用会阻碍DDR，并使细胞对电离辐射敏感，从而诱导细胞死亡。该抗体与AlexaFluor®488偶联。AlexaFluor®488是一种流行的鲜绿色荧光染料，具有高pH稳定性。

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Discovery Antibodies/Anti-Cannabinoid Receptor 1 (extracellular) Antibody/25 µl/ACR-001-25 µl

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