Cataloguenumbercrb2005224AntibodyAnti-KSHVORF65antibodyAntigenPeptideKLHconjugatedsyntheticpeptidecrb1200467eProteinIDGenBank:ABD28922.1.UniProtKB-Q2HR63AliasesKaposisarcoma-associatedherpesvirus(KSHV)ORF65,Humangammaherpesvirus8ORF65,HHV-8ORF65,Smallcapsomere-interactingproteinCross-ReactivityKSHVHostSpeciesRabbitAntibodyTypePolyclonalConcentration0.5mg/mlValidationWB(1:100),ELISA(1:1000)TargetKSHVORF65SpecificityProteinStorageTheproductshouldbestoredat-20°Cforforshorttermstorageandlongtermstorage.Avoidrepeatedfreeze/thawcycles.References

Lin,S.,Sun,R.,Heston,L.,Gradoville,L.,Shedd,D.,Haglund,K.,Rigsby,M.,Miller,G.(1997).Identification,expression,andimmunogenicityofKaposi"ssarcoma-associatedherpesvirus-encodedsmallviralcapsidantigen.JVirol,71(4),3069-76.PMID:9060668

Discovery Antibodies的Cyclin dependant kinase 2 (CDK2) is a serine/threonine protein kinase which controls both G1/S and G2/M transitions. CDKs along with cyclins and CDK inhibitors regulate cell cycle progression. Specific cyclins activate different CDKs; in early G1, CDK2 pairs with cyclin E to promote entry into the S phase before switching to partner with cyclin A to drive the cell through S phase. Once activated CDKs phosphorylate downstream proteins to initiate signalling cascades. CDK2 phosphorylates and inactivates the RB1 (pRb) tumour suppressor family of proteins.CDK的活动受到严格控制。CDK2活性可以被包括P21在内的一系列抑制剂抑制。细胞周期失调和增殖控制的丧失与细胞转化和癌症密切相关。CDK2在DNA损伤反应（DDR）中的细胞周期停滞中也似乎起着积极作用，它的抑制作用会阻碍DDR，并使细胞对电离辐射敏感，从而诱导细胞死亡。该抗体与AlexaFluor®488偶联。AlexaFluor®488是一种流行的鲜绿色荧光染料，具有高pH稳定性。