Catalogue numbercrb2005165AntibodyAnti-Histone H2B antibodyAntigen PeptideKLH conjugated synthetic peptide crb1200311eProtein IDUniProtKB - P62807AliasesHistone H2B type 1-C/E/F/G/ICross-ReactivityHuman, Rabbit, MouseHost Species RabbitAntibody TypePolyclonalConcentration1mg/mlValidation1:1000 (WB), 1:1000 (ELISA),TargetHistone H2BDisease AreaHistonesFamilyHistonesSpecificityProteinStorage This material is supplied in PBS containing 0.01% sodium azide and 1% trehalose. The product should be stored at +4°C for short term storage and -20°C for long term storage. Avoid repeated freeze/ thaw cycles. References

Cole, A., Clifton-Bligh, R. and Marsh, D. (2014). Histone H2B monoubiquitination: roles to play in human malignancy. Endoc-Related Cancer, 22(1), T19-T33. PMID: 24891457

Khan, M., Alam, K., Hassan, S. and Rizvi, M. (2017). Nitration of H2B histone elicits an immune response in experimental animals. Autoimmunity, 50(4), 232-240. PMID: 28737980

Mao, P., Kyriss, M., Hodges, A., Duan, M., Morris, R., Lavine, M., Topping, T., Gloss, L. and Wyrick, J. (2016). A basic domain in the histone H2B N-terminal tail is important for nucleosome assembly by FACT. Nucleic Acids Res, 44(19), 9142–9152. PMID: 27369377

Discovery Antibodies的Cyclin dependant kinase 2 (CDK2) is a serine/threonine protein kinase which controls both G1/S and G2/M transitions. CDKs along with cyclins and CDK inhibitors regulate cell cycle progression. Specific cyclins activate different CDKs; in early G1, CDK2 pairs with cyclin E to promote entry into the S phase before switching to partner with cyclin A to drive the cell through S phase. Once activated CDKs phosphorylate downstream proteins to initiate signalling cascades. CDK2 phosphorylates and inactivates the RB1 (pRb) tumour suppressor family of proteins.CDK的活动受到严格控制。CDK2活性可以被包括P21在内的一系列抑制剂抑制。细胞周期失调和增殖控制的丧失与细胞转化和癌症密切相关。CDK2在DNA损伤反应（DDR）中的细胞周期停滞中也似乎起着积极作用，它的抑制作用会阻碍DDR，并使细胞对电离辐射敏感，从而诱导细胞死亡。该抗体与AlexaFluor®488偶联。AlexaFluor®488是一种流行的鲜绿色荧光染料，具有高pH稳定性。