快报
欢迎光临蚂蚁淘在线！ 请登录 免费注册
商品
品牌
文章
热门搜索：
快报
品牌首页 品牌新闻 品牌简介 产品中心 品牌咨询 联系我们
品牌分类
品牌咨询
联系方式
公司地址
苏州工业园区生物纳米园A4#216
联系电话
4000-520-616 / 18915418616
传真号码
0512-67156496
电子邮箱
info@ebiomall.com
公司网址
https://www.ebiomall.com
蚂蚁淘在线 / 品牌中心 / Discovery / Discovery Antibodies/Anti-B2 Bradykinin Receptor (BDKRB2) Antibody/0.2 ml/ABR-012-0.2 ml

Discovery Antibodies/Anti-B2 Bradykinin Receptor (BDKRB2) Antibody/0.2 ml/ABR-012-0.2 ml

价格
￥9500.00
货号：ABR-012-0.2ml
浏览量：113
品牌：Discovery
服务
全国联保
正品保证
正规发票
签订合同
商品描述
Cat#:ABR-012
AlternativeNameB2R,BKR2,B2BKR,BKRB2, KininB2,BRADYB2
  • LyophilizedPowder
  • AntigenIncl.
    • Type:Polyclonal
    Host:Rabbit
    Reactivity:h,m,r
      • PeptideGKRFRKKSWEVYQG(C),correspondingtoaminoacidresidues336-349ofhumanB2R(Accession P30411).Intracellular,C-terminus.
        Anti-B2 Bradykinin Receptor (BDKRB2) Antibody
    Accession(Uniprot)NumberP30411
    GeneID624
    PeptideconfirmationConfirmedbyaminoacidanalysisandmassspectrometry.
    HomologyRat-12/13aminoacidresiduesidentical;mouse-11/13aminoacidresiduesidentical.
    RRIDAB_2039754.
    PurityAffinitypurifiedonimmobilizedantigen.
    FormLyophilizedpowder.Reconstitutedantibodycontainsphosphatebufferedsaline(PBS),pH7.4,1%BSA,0.05%NaN3.
    IsotypeRabbitIgG.
    StoragebeforereconstitutionTheantibodyshipsasalyophilizedpowderatroomtemperature.Uponarrival,itshouldbestoredat-20°C.
    Reconstitution50μlor0.2mldoubledistilledwater(DDW),dependingonthesamplesize.
    Antibodyconcentrationafterreconstitution0.75mg/ml.
    StorageafterreconstitutionThereconstitutedsolutioncanbestoredat4°Cforupto1week.Forlongerperiods,smallaliquotsshouldbestoredat-20°C.Avoidmultiplefreezingandthawing.Centrifugeallantibodypreparationsbeforeuse(10000xg5min).
    NegativecontrolantigenstoragebeforereconstitutionLyophilizedpowdercanbestoredintactatroomtemperaturefor2weeks.Forlongerperiods,itshouldbestoredat-20°C.
    Negativecontrolantigenreconstitution100µldoubledistilledwater(DDW).
    Negativecontrolantigenstorageafterreconstitution-20°C.
    PreadsorptionControl1μgpeptideper1μgantibody.
    StandardqualitycontrolofeachlotWesternblotanalysis.
    Applications:ic,if,ih,wb
    Mayalsoworkin:ifc*,ip*
      • Anti-B2 Bradykinin Receptor (BDKRB2) Antibody
        Westernblotanalysisofratbrainlysate:
        1. Anti-B2 BradykininReceptor(BDKRB2)Antibody(#ABR-012),(1:1000).
        2.Anti-B2 BradykininReceptor(BDKRB2)Antibody,preincubatedwiththecontrolpeptideantigen.
      • Anti-B2 Bradykinin Receptor (BDKRB2) Antibody
        Expressionof B2 bradykininreceptor inmousespinalcord
        Immunohistochemicalstainingofmousespinalcordusing Anti-B2 BradykininReceptor (BDKRB2) Antibody(#ABR-012).A.BKR2(red)appearsinseveralspinalcordneurons(triangles).B.Parvalbumin(green)appearsinneurons.C.MergeofBKR2 andparvalbuminshowsco-expressioninseveralneurons(triangles)butnotall(arrowinC).DAPIisusedasthecounterstain.
      • Rattrigeminalneuronprimarycultures(Kawaguchi,A. etal. (2015) Front.Cell.Neurosci. 9, 229.).
    References
    • 1.Walker,K.etal(1995)NeuRochem.Int.26,1.
    • 2.Böckmann,S.andPaegelow,I.(2000)J.Leukoc.Biol.68,587.
    • 3.Hess,J.F.etal.(2004)J.Pharmacol.Exp.Ther.310,488.
    • 4.Souza,D.G.etal.(2004)J.Immunol.172,2542.
    • 5.Calixto,J.B.etal.(2000)Pain87,1.

      • Kininsaresmallpeptides producedrapidlyfollowingtissueinjurythatserveasimportantmodulatorsofinflammationandpain.Intheperiphery,theactionsofkininsincludevasodilatation,increasedvascularpermeABIlity,stimulationofimmunecells,andinductionofpain.Kininsinthecentralnervoussystem(CNS)seemtoinitiateasimilarcascadeofeventsleADIngtoneuraltissuedamage,aswellaslonglastingdisturbancesaffectingblood-brainbarrierfunction.1

        Kinins,suchasBradykinin(BK),Lys-BK,desArg9-BK,andLys-desArg9-BK,exerttheiractionviatwodistinctreceptors:the B1 Bradykininreceptor (BKRB1)andtheB2 Bradykininreceptor(BKRB2).BKRB2isactivatedbyBKandLys-BKwhiledesArg9-BKandLys-desArg9-BKactivateBKRB1.2  ActivationofBKRB2liberatesmediatorsofvasculartone,fibrinolysis,andpain.BKRB2,whichmediatesmostofthephysiologicaleffectsofkinins,aswellasBKRB1,representpotentialtherapeutictargetsfortreatmentofinflammatorydisordersandcardiovasculardiseases.

        BothBKRB1andBKRB2aremembersoftheseven-transmembranedomain,Gprotein-coupledreceptor(GPCR)superfamilyandshareacommonstructureofsevenputativetransmembranedomains,anextracellularaminoterminus,andacytoplasmiccarboxyterminus.

        BKRB2isconstitutivelyandwidelyexpressedthroughouttheCNSandperipheralnervoussystemandonvariouscelltypesincludingendothelialcells,nervefibers,leukocytes,andmastcells.3-5

    Applicationkey:

    CBE-Cell-basedELISA,FC-Flowcytometry,ICC-Immunocytochemistry,IE-IndirectELISA,IFC-Indirectflowcytometry,
    IF-Immunofluorescence,IHC-Immunohistochemistry,IP-Immunoprecipitation,LCI-Livecellimaging,N-Neutralization,WB-Westernblot

    Speciesreactivitykey:

    H-Human,M-Mouse,R-Rat
    LyophilizedPowderNegativeControlAntigenIncluded
    receivea50µlfreetrialsample!
    Image&Title:

    Anti-B2 Bradykinin Receptor (BDKRB2) Antibody
    ExpressionofB2 bradykininreceptorinratTGneurons.Immunocytochemicalstainingofratprimarytrigeminalganglion(TG)neuronsusing Anti-B2 BradykininReceptor (BDKRB2) Antibody(#ABR-012).  Adaptedfrom Kawaguchi,A. etal. (2015) Front.Cell.Neurosci. 9, 229.withpermissionofFrontiers.

    Lastupdate:10/11/2019

    Anti-B2BradykininReceptor(BDKRB2)Antibody(#ABR-012)isahighlyspecificantibodydirectedagainstanepitopeofthehumanprotein.Theantibodycanbeusedinwesternblot,immunohistochemistry,andimmunocytochemistryapplications.IthasbeendesignedtorecognizeB2Rfromhuman,rat,andmousesamples.

    Forresearchpurposesonly,notforhumanuse
    Discovery Antibodies的Cyclin dependant kinase 2 (CDK2) is a serine/threonine protein kinase which controls both G1/S and G2/M transitions. CDKs along with cyclins and CDK inhibitors regulate cell cycle progression. Specific cyclins activate different CDKs; in early G1, CDK2 pairs with cyclin E to promote entry into the S phase before switching to partner with cyclin A to drive the cell through S phase. Once activated CDKs phosphorylate downstream proteins to initiate signalling cascades. CDK2 phosphorylates and inactivates the RB1 (pRb) tumour suppressor family of proteins.CDK的活动受到严格控制。CDK2活性可以被包括P21在内的一系列抑制剂抑制。细胞周期失调和增殖控制的丧失与细胞转化和癌症密切相关。CDK2在DNA损伤反应（DDR）中的细胞周期停滞中也似乎起着积极作用，它的抑制作用会阻碍DDR，并使细胞对电离辐射敏感，从而诱导细胞死亡。该抗体与AlexaFluor®488偶联。AlexaFluor®488是一种流行的鲜绿色荧光染料，具有高pH稳定性。

    • 资质认证

      获得国家资质，权威认证！

    • 全国联保

      全国联保，官方无忧售后

    • 正规发票

      正规发票，放心购买

    • 签订合同

      签订合同，保障您的权益

    购物指南
    购物流程
    注册登录
    账户管理
    订单查看
    常见问题
    FAQS
    蚁豆兑换
    物流说明
    评论规则
    发票说明
    价格说明
    支付说明
    服务协议
    版权声明
    诚信保障
    免责申明
    销售协议
    隐私条款
    法律申明
    售后服务
    退换货政策
    工作时间
    退款说明
    售后支持
    售后申请表模板列表
    关于我们
    公司简介
    联系我们
    资质证书
    人才招聘
    商务合作
    万众创业
    网址导航
    蚂蚁淘商城
    科研狗
    苏州蚂蚁淘
    生物信息网
    现货促销

    微信公众号

    Chemicell中国 | 转染试剂24765 | percipiobio价格 | Probetex价格 | bioroute华东代理 | Glixx Laboratories厂家 | Sigma代理 | 蚂蚁淘 | 染色体倍性分析仪

    copyright©2005-2021 蚂蚁淘在线版权所有　苏州蚂蚁淘生物科技有限公司 www.assay-online.com ICP号：苏ICP备17049038号-16

    /**/