Cataloguenumbercrb2005165AntibodyAnti-HistoneH2BantibodyAntigenPeptideKLHconjugatedsyntheticpeptidecrb1200311eProteinIDUniProtKB-P62807AliasesHistoneH2Btype1-C/E/F/G/ICross-ReactivityHuman,Rabbit,MouseHostSpeciesRabbitAntibodyTypePolyclonalConcentration1mg/mlValidation1:1000(WB),1:1000(ELISA),TargetHistoneH2BDiseaseAreaHistonesFamilyHistonesSpecificityProteinStorageThismaterialissuppliedinPBScontaining0.01%sodiumazideand1%trehalose.Theproductshouldbestoredat+4°Cforshorttermstorageand-20°Cforlongtermstorage.Avoidrepeatedfreeze/thawcycles.References

Cole,A.,Clifton-Bligh,R.andMarsh,D.(2014).HistoneH2Bmonoubiquitination:rolestoplayinhumanmalignancy.Endoc-RelatedCancer,22(1),T19-T33.PMID:24891457

Khan,M.,Alam,K.,Hassan,S.andRizvi,M.(2017).NitrationofH2Bhistoneelicitsanimmuneresponseinexperimentalanimals.Autoimmunity,50(4),232-240.PMID:28737980

Mao,P.,Kyriss,M.,Hodges,A.,Duan,M.,Morris,R.,Lavine,M.,Topping,T.,Gloss,L.andWyrick,J.(2016).AbasicdomaininthehistoneH2BN-terminaltailisimportantfornucleosomeassemblybyFACT.NucleicAcidsRes,44(19),9142–9152.PMID:27369377

Discovery Antibodies的Cyclin dependant kinase 2 (CDK2) is a serine/threonine protein kinase which controls both G1/S and G2/M transitions. CDKs along with cyclins and CDK inhibitors regulate cell cycle progression. Specific cyclins activate different CDKs; in early G1, CDK2 pairs with cyclin E to promote entry into the S phase before switching to partner with cyclin A to drive the cell through S phase. Once activated CDKs phosphorylate downstream proteins to initiate signalling cascades. CDK2 phosphorylates and inactivates the RB1 (pRb) tumour suppressor family of proteins.CDK的活动受到严格控制。CDK2活性可以被包括P21在内的一系列抑制剂抑制。细胞周期失调和增殖控制的丧失与细胞转化和癌症密切相关。CDK2在DNA损伤反应（DDR）中的细胞周期停滞中也似乎起着积极作用，它的抑制作用会阻碍DDR，并使细胞对电离辐射敏感，从而诱导细胞死亡。该抗体与AlexaFluor®488偶联。AlexaFluor®488是一种流行的鲜绿色荧光染料，具有高pH稳定性。