Cataloguenumbercrb2005041AntibodyAnti-IL-11antibodyAntigenPeptideKLHconjugatedsyntheticpeptidecrb1200323eProteinIDUniProtKB-P20809AliasesInterleukin-11,ADIpogenesisinhibitoryfactorCross-ReactivityHumanHostSpeciesRabbitAntibodyTypePolyclonalConcentration1mg/mlValidation1:500(WB),1:1000(ELISA)TargetIL-11DiseaseAreaInflammatoryFamilyCytokines(IL-6)StorageThismaterialissuppliedinPBScontaining0.01%sodiumazideand1%trehalose.Theproductshouldbestoredat+4°Cforshorttermstorageand-20°Cforlongtermstorage.Avoidrepeatedfreeze/thawcycles.References

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Sokolov,A.,Kazakov,A.,Solovyev,V.,Ismailov,R.,Uversky,V.,Lapteva,Y.,Mikhailov,R.,Pavlova,E.,Terletskaya,I.,Ermolina,L.,Permyakov,S.andPermyakov,E.(2016).Expression,Purification,andCharacterizationofInterleukin-11Orthologues.Molecules,21(12),1632.PMID:27916836

Discovery Antibodies的Cyclin dependant kinase 2 (CDK2) is a serine/threonine protein kinase which controls both G1/S and G2/M transitions. CDKs along with cyclins and CDK inhibitors regulate cell cycle progression. Specific cyclins activate different CDKs; in early G1, CDK2 pairs with cyclin E to promote entry into the S phase before switching to partner with cyclin A to drive the cell through S phase. Once activated CDKs phosphorylate downstream proteins to initiate signalling cascades. CDK2 phosphorylates and inactivates the RB1 (pRb) tumour suppressor family of proteins.CDK的活动受到严格控制。CDK2活性可以被包括P21在内的一系列抑制剂抑制。细胞周期失调和增殖控制的丧失与细胞转化和癌症密切相关。CDK2在DNA损伤反应（DDR）中的细胞周期停滞中也似乎起着积极作用，它的抑制作用会阻碍DDR，并使细胞对电离辐射敏感，从而诱导细胞死亡。该抗体与AlexaFluor®488偶联。AlexaFluor®488是一种流行的鲜绿色荧光染料，具有高pH稳定性。