Cataloguenumbercrb2005049AntibodyAnti-GLT-1antibodyAntigenPeptideKLHconjugatedsyntheticpeptidecrb1200000eProteinIDSwissProt-P60709AliasesGLT1,EAAT2,ExcitotoxicAminoAcidTransporter2,ExcitatoryAminoAcidTransporter2,SoluteCarrierFamily1Member2,Sodium-DependentGlutamate/AspartateTransporter2,Glutamate/AspartateTransporterIICross-ReactivityMouse,HumanHostSpeciesRabbitAntibodyTypePolyclonalConcentration1mg/mlValidation1:1000(WB),1:1000(ELISA)TargetGLT-1DiseaseAreaNeurodegenerativediseasesFamilyGlutamatetransporterSpecificityProteinStorageThismaterialissuppliedinPBScontaining0.01%sodiumazideand1%trehalose.Theproductshouldbestoredat+4°Cforshorttermstorageand-20°Cforlongtermstorage.Avoidrepeatedfreeze/thawcycles.References

AlAwaBDh,S.,Gupta-Agarwal,S.,Sheehan,D.,Muir,J.,Norkett,R.,Twelvetrees,A.,Griffin,L.andKittler,J.(2016).NeuronalactivitymediatedregulationofglutamatetransporterGLT-1surfacediffusioninratastrocytesindissociatedandslicecultures.Glia,64(7),1252-1264.PMID:27189737

Meabon,J.,Lee,A.,Meeker,K.,Bekris,L.,Fujimura,R.,Yu,C.,Watson,G.,Pow,D.,Sweet,I.andCook,D.(2011).DifferentialExpressionoftheGlutamateTransporterGLT-1inPancreas.JHistochemCytochem,60(2),139-151.PMID:22114258

Santa_Cruz_alternativesc-15317,sc-7760 Discovery Antibodies的Cyclin dependant kinase 2 (CDK2) is a serine/threonine protein kinase which controls both G1/S and G2/M transitions. CDKs along with cyclins and CDK inhibitors regulate cell cycle progression. Specific cyclins activate different CDKs; in early G1, CDK2 pairs with cyclin E to promote entry into the S phase before switching to partner with cyclin A to drive the cell through S phase. Once activated CDKs phosphorylate downstream proteins to initiate signalling cascades. CDK2 phosphorylates and inactivates the RB1 (pRb) tumour suppressor family of proteins.CDK的活动受到严格控制。CDK2活性可以被包括P21在内的一系列抑制剂抑制。细胞周期失调和增殖控制的丧失与细胞转化和癌症密切相关。CDK2在DNA损伤反应（DDR）中的细胞周期停滞中也似乎起着积极作用，它的抑制作用会阻碍DDR，并使细胞对电离辐射敏感，从而诱导细胞死亡。该抗体与AlexaFluor®488偶联。AlexaFluor®488是一种流行的鲜绿色荧光染料，具有高pH稳定性。