Catalogue numbercrb2005219AntibodyAnti-GSK-3β antibodyAntigen PeptideKLH conjugated synthetic peptide crb1200462eProtein IDUniProtKB - P49841AliasesGlycogen synthase kinase-3 beta, GSK3 beta, GSK3B, Serine/threonine-protein kinase GSK3B Cross-ReactivityhumanHost Species RabbitAntibody TypePolyclonalConcentration0.2 mg/mlValidationWB (1:1000), ELISA (1:1000)TargetGSK-3βDisease AreaSignal transduction, Biological rhythms, Carbohydrate metabolism, Differentiation, Glycogen metabolism, Neurogenesis, Wnt signaling pathwayFamilyprotein kinase superfamilySuper Family CMGC Ser/Thr protein kinase family. GSK-3 subfamily.SpecificityProtein Storage The product should be stored at -20°C for for short term storage and long term storage. Avoid repeated freeze/ thaw cycles. References

Gao, S., Li, S., Duan, X., Gu, Z., Ma, Z., Yuan, X., Feng, X. and Wang, H. (2017). Inhibition of glycogen synthase kinase 3 beta (GSK3β) suppresses the progression of oesophageal squamous cell carcinoma by modifying STAT3 activity. Mol Carcinog, 56(10), 2301-2316. PMID: 28574599

Zeng, J., Liu, D., Qiu, Z., Huang, Y., Chen, B., Wang, L., Xu, H., Huang, N., Liu, L. and Li, W. (2014). GSK3β Overexpression Indicates Poor Prognosis and Its Inhibition Reduces Cell Proliferation and Survival of Non-Small Cell Lung Cancer Cells. PLoS ONE, 9(3), e91231. PMID: 24618715

Discovery Antibodies的Cyclin dependant kinase 2 (CDK2) is a serine/threonine protein kinase which controls both G1/S and G2/M transitions. CDKs along with cyclins and CDK inhibitors regulate cell cycle progression. Specific cyclins activate different CDKs; in early G1, CDK2 pairs with cyclin E to promote entry into the S phase before switching to partner with cyclin A to drive the cell through S phase. Once activated CDKs phosphorylate downstream proteins to initiate signalling cascades. CDK2 phosphorylates and inactivates the RB1 (pRb) tumour suppressor family of proteins.CDK的活动受到严格控制。CDK2活性可以被包括P21在内的一系列抑制剂抑制。细胞周期失调和增殖控制的丧失与细胞转化和癌症密切相关。CDK2在DNA损伤反应（DDR）中的细胞周期停滞中也似乎起着积极作用，它的抑制作用会阻碍DDR，并使细胞对电离辐射敏感，从而诱导细胞死亡。该抗体与AlexaFluor®488偶联。AlexaFluor®488是一种流行的鲜绿色荧光染料，具有高pH稳定性。