Cataloguenumbercrb2005163AntibodyAnti-EGLN2/PHD1antibodyAntigenPeptideKLHconjugatedsyntheticpeptidecrb1200422eProteinIDUniprotID:Q96KS0AliasesEglninehomolog2,EGLN2Isoformp43,EGLN2Isoformp40,Prolylhydroxylasedomain-containingprotein1,PHD1,Hypoxia-inducIBLefactorprolylhydroxylase1,HIF-PH1,HPH-1Cross-ReactivityHumanHostSpeciesRabbitAntibodyTypePolyclonalConcentration0.2mg/mlValidationWB(1:1000in2%BSA),ELISA(1:1000)TargetEGLN2SpecificityProteinStorageTheproductshouldbestoredat-20°Cforforshorttermstorageandlongtermstorage.Avoidrepeatedfreeze/thawcycles.References

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Zhang,J.,Wang,C.,Chen,X.,Takada,M.,Fan,C.,Zheng,X.,Wen,H.,Liu,Y.,Wang,C.,Pestell,R.,Aird,K.,Kaelin,W.,Liu,X.andZhang,Q.(2015).EglN2associateswiththeNRF1‐PGC1αcomplexandcontrolsmitochondrialfunctioninbreastcancer.EMBOJ,34(23),2953-2970.PMID:26492917

Discovery Antibodies的Cyclin dependant kinase 2 (CDK2) is a serine/threonine protein kinase which controls both G1/S and G2/M transitions. CDKs along with cyclins and CDK inhibitors regulate cell cycle progression. Specific cyclins activate different CDKs; in early G1, CDK2 pairs with cyclin E to promote entry into the S phase before switching to partner with cyclin A to drive the cell through S phase. Once activated CDKs phosphorylate downstream proteins to initiate signalling cascades. CDK2 phosphorylates and inactivates the RB1 (pRb) tumour suppressor family of proteins.CDK的活动受到严格控制。CDK2活性可以被包括P21在内的一系列抑制剂抑制。细胞周期失调和增殖控制的丧失与细胞转化和癌症密切相关。CDK2在DNA损伤反应（DDR）中的细胞周期停滞中也似乎起着积极作用，它的抑制作用会阻碍DDR，并使细胞对电离辐射敏感，从而诱导细胞死亡。该抗体与AlexaFluor®488偶联。AlexaFluor®488是一种流行的鲜绿色荧光染料，具有高pH稳定性。