Catalogue number	crb2115008e
Antibody	Alexa Fluor® 488 Anti-NR1 4b Antibody
Antigen Peptide	KLH conjugated synthetic peptide crb1200277e
Protein ID	UniProtKB - Q05586
Aliases	NR1, MRD8, NMDAR1, NMDA Zeta-1, NMD-R1, GluN1, glutamate ionotropic receptor NMDA type subunit 1, NMDA NR1 Subunit
Cross-Reactivity	Human, Rat, Mouse
Host Species	Anti-Rabbit
Antibody Type	Polyclonal
Label	Labelled with Alexa Fluor® 488 under optimal conditions. Ex: 495nm Em:519nm
Concentration	0.64mg/ml
Validation	ELISA
Target	NR1 4b
Disease Area	Neurodegenerative diseases
Family	Glutamate-gated ion channel family.
Specificity	NR1 Splice variant 4b
Storage	Supplied in PBS containing 0.01% sodium azide. The product should be stored undiluted and protected from prolonged exposure to light. Short term storage between 2-8°C and long term storage below -20°C
References	Donaldson, L. and Beazley-Long, N. (2016). Alternative RNA splicing: contribution to pain and potential therapeutic strategy. Drug Discov Today, 21(11), 1787-1798. PMID: 27329269 Ewald, R. (2009). Cloning and phylogenetic analysis of NMDA receptor subunits NR1, NR2A and NR2B in Xenopus laevis tadpoles. Front Mol Neurosci, 2. PMID: 19826620

Discovery Antibodies的Cyclin dependant kinase 2 (CDK2) is a serine/threonine protein kinase which controls both G1/S and G2/M transitions. CDKs along with cyclins and CDK inhibitors regulate cell cycle progression. Specific cyclins activate different CDKs; in early G1, CDK2 pairs with cyclin E to promote entry into the S phase before switching to partner with cyclin A to drive the cell through S phase. Once activated CDKs phosphorylate downstream proteins to initiate signalling cascades. CDK2 phosphorylates and inactivates the RB1 (pRb) tumour suppressor family of proteins.CDK的活动受到严格控制。CDK2活性可以被包括P21在内的一系列抑制剂抑制。细胞周期失调和增殖控制的丧失与细胞转化和癌症密切相关。CDK2在DNA损伤反应（DDR）中的细胞周期停滞中也似乎起着积极作用，它的抑制作用会阻碍DDR，并使细胞对电离辐射敏感，从而诱导细胞死亡。该抗体与AlexaFluor®488偶联。AlexaFluor®488是一种流行的鲜绿色荧光染料，具有高pH稳定性。