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蚂蚁淘在线 / 品牌中心 / Discovery / Discovery Antibodies/Anti-KV1.3 (KCNA3) (extracellular)-FITC Antibody/2 x 50 µl/APC-101-F-2 x 50 µl

Discovery Antibodies/Anti-KV1.3 (KCNA3) (extracellular)-FITC Antibody/2 x 50 µl/APC-101-F-2 x 50 µl

价格

￥14740.00

货号：APC-101-F-2x50µl

浏览量：127

品牌：Discovery

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商品描述

Cat#:APC-101-F

AlternativeNamePotassiumvoltage-gatedchannelsubfamilyAmember3

LyophilizedPowder

Type:Polyclonal

Host:Rabbit

Reactivity:h,m,r

Immunogen-+

Accession(Uniprot)NumberP22001

GeneID3738

PeptideconfirmationConfirmedbyaminoacidanalysisandmassspectrometry.

HomologyRat,mouse -12/14aminoacidresiduesidentical.

RRIDAB_2040147.

PurityAffinitypurifiedonimmobilizedantigen.

FormLyophilizedpowder.Reconstitutedantibodycontainsphosphatebufferedsaline(PBS),pH7.4,1%BSA,0.05%NaN₃.

IsotypeRabbitIgG.

LabelFluoresceinisothiocyanate(FITC).

StoragebeforereconstitutionTheantibodyshipsasalyophilizedpowderatroomtemperature.Uponarrival,itshouldbestoredat-20°C.

Reconstitution50µldoubledistilledwater(DDW).

Antibodyconcentrationafterreconstitution1mg/ml.

StorageafterreconstitutionThereconstitutedsolutioncanbestoredat4°C,protectedfromthelight,forupto1week.Forlongerperiods,smallaliquotsshouldbestoredat-20°C.Avoidmultiplefreezingandthawing.Centrifugeallantibodypreparationsbeforeuse(10000×g5min).

StandardqualitycontrolofeachlotWesternblotanalysis(unlabeledantibody,#APC-101),anddirectflowcytometry(labeledantibody).

Applications:fc,ic,if,lci

Directflowcytometry-+

Livecellimaging/Immunocytochemistry-+

References

1.Chandy,K.G.etal.(2001)Toxicon39,1269.

2.Koo,G.C.etal.(1997)J.Immunol.158,5120.

3.Grissmer,S.etal.(1994)Mol.Pharmacol.45,1227.

4.Garcia-Calvo,M.etal.(1993)J.Biol.Chem.268,18866

5.Garcia,M.L.etal.(1994)Biochemistry33,6834.

6.Koschak,A.etal.(1998)J.Biol.Chem.273,2639.

7.Kalman,K.etal.(1998)J.Biol.Chem.273,32697.

Scientificbackground-+

LyophilizedPowder

Lastupdate:16/01/2020

Anti-K_V1.3(KCNA3)(extracellular)Antibody(#APC-101)isahighlyspecificantibodydirectedagainstanextracellularepitopeofthehumanprotein.Theantibodycanbeusedinwesternblot,immunohistochemistry,livecellimaging,andindirectflowcytometryapplications.IthasbeendesignedtorecognizeK_V1.3potassiumchannelfromhuman,mouse,andratsamples.

Anti-K_V1.3(KCNA3)(extracellular)-FITCAntibody(#APC-101-F)isdirectlyconjugatedtofluoresceinisothiocyanate(FITC).Thislabeledantibody canbeusedinimmunofluorescentapplicationssuchasdirectflowcytometryandlivecellimaging.

Forresearchpurposesonly,notforhumanuse

Discovery Antibodies的Cyclin dependant kinase 2 (CDK2) is a serine/threonine protein kinase which controls both G1/S and G2/M transitions. CDKs along with cyclins and CDK inhibitors regulate cell cycle progression. Specific cyclins activate different CDKs; in early G1, CDK2 pairs with cyclin E to promote entry into the S phase before switching to partner with cyclin A to drive the cell through S phase. Once activated CDKs phosphorylate downstream proteins to initiate signalling cascades. CDK2 phosphorylates and inactivates the RB1 (pRb) tumour suppressor family of proteins.CDK的活动受到严格控制。CDK2活性可以被包括P21在内的一系列抑制剂抑制。细胞周期失调和增殖控制的丧失与细胞转化和癌症密切相关。CDK2在DNA损伤反应（DDR）中的细胞周期停滞中也似乎起着积极作用，它的抑制作用会阻碍DDR，并使细胞对电离辐射敏感，从而诱导细胞死亡。该抗体与AlexaFluor®488偶联。AlexaFluor®488是一种流行的鲜绿色荧光染料，具有高pH稳定性。

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Discovery Antibodies/Anti-KV1.3 (KCNA3) (extracellular)-FITC Antibody/2 x 50 µl/APC-101-F-2 x 50 µl

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