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蚂蚁淘在线 / 品牌中心 / Discovery / Discovery Antibodies/Anti-BAI1 (extracellular)-FITC Antibody/50 µl/ABR-021-F-50 µl

Discovery Antibodies/Anti-BAI1 (extracellular)-FITC Antibody/50 µl/ABR-021-F-50 µl

价格

￥10540.00

货号：ABR-021-F-50µl

浏览量：127

品牌：Discovery

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商品描述

Cat#:ABR-021-F

AlternativeNameBrain-specificangiogenesisinhibitor1,AdhesionGprotein-coupledreceptorB1,ADGRB1,GDAIF

LyophilizedPowder

Type:Polyclonal

Host:Rabbit

Reactivity:h,m,r

Immunogen-+

Accession(Uniprot)NumberQ3UHD1

GeneID107831

PeptideconfirmationConfirmedbyaminoacidanalysisandmassspectrometry.

HomologyRat,human–identical.

RRIDAB_2756543.

PurityAffinitypurifiedonimmobilizedantigen.

FormLyophilizedpowder.Reconstitutedantibodycontainsphosphatebufferedsaline(PBS),pH7.4,1%BSA,0.05%NaN₃.

IsotypeRabbitIgG.

SpecificityTheantibodywillrecognizetheintactBAI1receptoraswellastheproteolyticallyprocessedN-terminalfragment.ThisfragmentisalsoknownasVasculostatin(Vstat120).

LabelFluoresceinisothiocyanate(FITC).

StoragebeforereconstitutionTheantibodyshipsasalyophilizedpowderatroomtemperature.Uponarrival,itshouldbestoredat-20°C.

Reconstitution50µldoubledistilledwater(DDW).

Antibodyconcentrationafterreconstitution1mg/ml.

StorageafterreconstitutionThereconstitutedsolutioncanbestoredat4°C,protectedfromthelight,forupto1week.Forlongerperiods,smallaliquotsshouldbestoredat-20°C.Avoidmultiplefreezingandthawing.Centrifugeallantibodypreparationsbeforeuse(10000×g5min).

StandardqualitycontrolofeachlotWesternblotanalysis(unlabeledantibody,#ABR-021),anddirectflowcytometry(labeledantibody).

Applications:fc

Mayalsoworkin:ic*,lci*

Directflowcytometry-+

References

1.Park,D.etal.(2007)Nature450,430.

2.Cork,S.M.etal.(2011)J.Mol.Med.89,743.

3.deFraipont,F.etal.(2001)TrendsMol.Med.7,401.

4.Oda,K.etal.(1999)Cytogenet.Cell.Genet.84,75.

5.Cork,S.M.etal.(2012)Oncogene31,5144.

6.Shiratsuchi,T.etal.(1997)Cytogenet.Cell.Genet.79,103.

7.Hatanaka,H.etal.(2000)Int.J.Mol.Med.5,181.

8.Fukushima,Y.etal.(1998)Int.J.Oncol.13,967.

Scientificbackground-+

LyophilizedPowder

Lastupdate:27/11/2019

Anti-BAI1(extracellular)Antibody(#ABR-021)isahighlyspecificantibodydirectedagainstanepitopeofthemouseprotein.Theantibodycanbeusedinwesternblot,immunohistochemistry,andindirectlivecellflowcytometryapplications.IthasbeendesignedtorecognizeBAI1fromrat,mouse,andhumansamples.

Anti-BAI1(extracellular)-FITCAntibody(#ABR-021-F)isdirectlyconjugatedtofluoresceinisothiocyanate(FITC).Thislabeledantibodycanbeusedinimmunofluorescentapplicationssuchasdirectlivecellflowcytometry.

Forresearchpurposesonly,notforhumanuse

Discovery Antibodies的Cyclin dependant kinase 2 (CDK2) is a serine/threonine protein kinase which controls both G1/S and G2/M transitions. CDKs along with cyclins and CDK inhibitors regulate cell cycle progression. Specific cyclins activate different CDKs; in early G1, CDK2 pairs with cyclin E to promote entry into the S phase before switching to partner with cyclin A to drive the cell through S phase. Once activated CDKs phosphorylate downstream proteins to initiate signalling cascades. CDK2 phosphorylates and inactivates the RB1 (pRb) tumour suppressor family of proteins.CDK的活动受到严格控制。CDK2活性可以被包括P21在内的一系列抑制剂抑制。细胞周期失调和增殖控制的丧失与细胞转化和癌症密切相关。CDK2在DNA损伤反应（DDR）中的细胞周期停滞中也似乎起着积极作用，它的抑制作用会阻碍DDR，并使细胞对电离辐射敏感，从而诱导细胞死亡。该抗体与AlexaFluor®488偶联。AlexaFluor®488是一种流行的鲜绿色荧光染料，具有高pH稳定性。

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Discovery Antibodies/Anti-BAI1 (extracellular)-FITC Antibody/50 µl/ABR-021-F-50 µl

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