Cataloguenumbercrb2005004AntibodyAnti-PeroxiredoxinSO2/3AntibodyAntigenPeptideKLHconjugatedsyntheticpeptidecrb1200280eProteinIDUniProtKB-Q06830,P32119,P30048,Q13162AliasesPRDX3,Thioredoxin-dependentperoxidereductase,mitochondrial/Antioxidantprotein1,AOP-1,HBC189,PRDX2,PRXIII,Peroxiredoxin,PRP,PRXII,NaturalKillercell-enhancingfactorB,NKEF-B,Thiol-specificantioxidantprotein,TSACross-ReactivityHuman,frogHostSpeciesAnti-RabbitAntibodyTypePolyclonalLabelUnconjugatedConcentration1mg/mlValidationWB/ELISATargetPeroxiredoxinSO2/3DiseaseAreaCancer,CircADIanRhythmFamilyPeroxiredoxinfamilySpecificityPTM-oxidisedformPost-translationalModificationOveroxidizedformofPeroxiredoxin1-4StorageThismaterialissuppliedinPBScontaining0.01%sodiumazideand1%trehalose.Theproductshouldbestoredat+4°Cforshorttermstorageand-20°Cforlongtermstorage.Avoidrepeatedfreeze/thawcycles.CitationsMilev,N.,Rey,G.,Valekunja,U.,Edgar,R.,O’Neill,J.andReddy,A.(2015).AnalysisoftheRedoxOscillationsintheCircadianClockwork.MethodsEnzymol,185-210.PMID:25707278References

Ishida,Y.,Takikawa,M.,Suzuki,T.,Nagahama,M.andOgasawara,Y.(2014).IrreversIBLehyperoxidationofperoxiredoxin2iscausedbytert-butylhydroperoxideinhumanredbloodcells.FEBSOpenBio,4(1),848-852.PMID:25379381

Park,S-J.,Kim,T-S.,Kim,J-M.,Chang,K-T.,Lee,H-S.andLee,D-S.(2015).RepeatedSuperovulationviaPMSG/hCGAdmiNISTrationInduces2-CysPeroxiredoxinsExpressionandOveroxidationintheReproductiveTractsofFemaleMice.MolCells,38(12),1071-1078.PMID:26486164

Discovery Antibodies的Cyclin dependant kinase 2 (CDK2) is a serine/threonine protein kinase which controls both G1/S and G2/M transitions. CDKs along with cyclins and CDK inhibitors regulate cell cycle progression. Specific cyclins activate different CDKs; in early G1, CDK2 pairs with cyclin E to promote entry into the S phase before switching to partner with cyclin A to drive the cell through S phase. Once activated CDKs phosphorylate downstream proteins to initiate signalling cascades. CDK2 phosphorylates and inactivates the RB1 (pRb) tumour suppressor family of proteins.CDK的活动受到严格控制。CDK2活性可以被包括P21在内的一系列抑制剂抑制。细胞周期失调和增殖控制的丧失与细胞转化和癌症密切相关。CDK2在DNA损伤反应（DDR）中的细胞周期停滞中也似乎起着积极作用，它的抑制作用会阻碍DDR，并使细胞对电离辐射敏感，从而诱导细胞死亡。该抗体与AlexaFluor®488偶联。AlexaFluor®488是一种流行的鲜绿色荧光染料，具有高pH稳定性。