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蚂蚁淘在线 / 品牌中心 / Discovery / Discovery Antibodies/Anti-IP3 Receptor-2 (ITPR2) Antibody/0.2 ml/ACC-116-0.2 ml

Discovery Antibodies/Anti-IP3 Receptor-2 (ITPR2) Antibody/0.2 ml/ACC-116-0.2 ml

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￥9500.00

货号：ACC-116-0.2ml

浏览量：127

品牌：Discovery

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商品描述

Cat#:ACC-116

AlternativeNameInositol1,4,5-trisphosphatereceptortype2,IP3R2,InsP3R2,IP₃receptorisoform2

LyophilizedPowder

AntigenIncl.

Type:Polyclonal

Host:Rabbit

Reactivity:r

Mayalsoworkin:h*,m*

Immunogen-+

Accession(Uniprot)NumberP29995

GeneID81678

PeptideconfirmationConfirmedbyaminoacidanalysisandmassspectrometry.

HomologyMouse,human-13/14aminoacidresiduesidentical.

RRIDAB_2340910.

PurityAffinitypurifiedonimmobilizedantigen.

FormLyophilizedpowder.Reconstitutedantibodycontainsphosphatebufferedsaline(PBS),pH7.4,1%BSA,0.05%NaN₃.

IsotypeRabbitIgG.

StoragebeforereconstitutionTheantibodyshipsasalyophilizedpowderatroomtemperature.Uponarrival,itshouldbestoredat-20°C.

Reconstitution25µl,50µlor0.2mldoubledistilledwater(DDW),dependingonthesamplesize.

Antibodyconcentrationafterreconstitution0.8mg/ml.

StorageafterreconstitutionThereconstitutedsolutioncanbestoredat4°Cforupto1week.Forlongerperiods,smallaliquotsshouldbestoredat-20°C.Avoidmultiplefreezingandthawing.Centrifugeallantibodypreparationsbeforeuse(10000xg5min).

NegativecontrolantigenstoragebeforereconstitutionLyophilizedpowdercanbestoredintactatroomtemperaturefor2weeks.Forlongerperiods,itshouldbestoredat-20°C.

Negativecontrolantigenreconstitution100µldoubledistilledwater(DDW).

Negativecontrolantigenstorageafterreconstitution-20°C.

PreadsorptionControl1µgpeptideper1µgantibody.

StandardqualitycontrolofeachlotWesternblotanalysis.

Applications:if,ih,wb

Mayalsoworkin:ic*,ifc*,ip*

Westernblot-+

Immunohistochemistry-+

References

1.Furuichi,T.etal.(1989)Nature342,32.

2.Berridge,M.J.etal.(2003)Nat.Rev.Mol.CellBiol.4,517.

3.Furuichi,T.etal.(1994)Curr.Opin.Neurobiol.4,294.

4.Varnai,P.etal.(2005)Proc.Natl.Acad.Sci.U.S.A.102,7859.

5.Fujino,I.etal.(1995)CellTissueRes.280,201.

6.Yaroslavskiy,B.B.etal.(2007)J.CellSci.120,2884.

Scientificbackground-+

LyophilizedPowderNegativeControlAntigenIncluded

Clickheretoreceivea25µlfreetrialsample!

Lastupdate:10/11/2019

Anti-IP₃Receptor-2(ITPR2)Antibody(#ACC-116)isahighlyspecificantibodydirectedagainstanepitopeoftheratprotein.Theantibody canbeusedinwesternblotandimmunohistochemistryapplications.IthasbeendesignedtorecognizeIP3R2fromrat,mouseandhumansamples.

Forresearchpurposesonly,notforhumanuse

Discovery Antibodies的Cyclin dependant kinase 2 (CDK2) is a serine/threonine protein kinase which controls both G1/S and G2/M transitions. CDKs along with cyclins and CDK inhibitors regulate cell cycle progression. Specific cyclins activate different CDKs; in early G1, CDK2 pairs with cyclin E to promote entry into the S phase before switching to partner with cyclin A to drive the cell through S phase. Once activated CDKs phosphorylate downstream proteins to initiate signalling cascades. CDK2 phosphorylates and inactivates the RB1 (pRb) tumour suppressor family of proteins.CDK的活动受到严格控制。CDK2活性可以被包括P21在内的一系列抑制剂抑制。细胞周期失调和增殖控制的丧失与细胞转化和癌症密切相关。CDK2在DNA损伤反应（DDR）中的细胞周期停滞中也似乎起着积极作用，它的抑制作用会阻碍DDR，并使细胞对电离辐射敏感，从而诱导细胞死亡。该抗体与AlexaFluor®488偶联。AlexaFluor®488是一种流行的鲜绿色荧光染料，具有高pH稳定性。

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Discovery Antibodies/Anti-IP3 Receptor-2 (ITPR2) Antibody/0.2 ml/ACC-116-0.2 ml

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