Catalogue numbercrb2005276AntibodyAnti-PERK antibodyAntigen PeptideDrosophila PERK kinase domain recombinant proteinProtein IDUniProtKB - Q9NIV1 (E2AK3_DROME)AliasesDrosophila PEK (pancreatic eIF2α kinase), CG2087, Drosophila Eukaryotic translation initiation factor 2-alpha kinase (E2AK3)Cross-ReactivityDrosophila melanogasterHost Species RabbitAntibody TypePolyclonalConcentrationantiserumValidation1:1000 (WB)Disease AreaUnfolded protein response, Wolcott Rallison Syndrome / diabetes mellitusFamilyserine/threonine kinasesSuper FamilyeIF2α kinasesCitationsMalzer E, Daly ML, Moloney A, Sendall TJ, Thomas SE, Ryder E, Ryoo HD, Crowther DC, Lomas DA, Marciniak SJ. (2010) J Cell Sci. Impaired tissue growth is mediated by checkpoint kinase 1 (CHK1) in the integrated stress response. 1;123(Pt 17):2892-900. doi: 10.1242/jcs.070078. PMID: 20682638 Discovery Antibodies的Cyclin dependant kinase 2 (CDK2) is a serine/threonine protein kinase which controls both G1/S and G2/M transitions. CDKs along with cyclins and CDK inhibitors regulate cell cycle progression. Specific cyclins activate different CDKs; in early G1, CDK2 pairs with cyclin E to promote entry into the S phase before switching to partner with cyclin A to drive the cell through S phase. Once activated CDKs phosphorylate downstream proteins to initiate signalling cascades. CDK2 phosphorylates and inactivates the RB1 (pRb) tumour suppressor family of proteins.CDK的活动受到严格控制。CDK2活性可以被包括P21在内的一系列抑制剂抑制。细胞周期失调和增殖控制的丧失与细胞转化和癌症密切相关。CDK2在DNA损伤反应（DDR）中的细胞周期停滞中也似乎起着积极作用，它的抑制作用会阻碍DDR，并使细胞对电离辐射敏感，从而诱导细胞死亡。该抗体与AlexaFluor®488偶联。AlexaFluor®488是一种流行的鲜绿色荧光染料，具有高pH稳定性。