Catalogue number	crb2115011e
Antibody	Alexa Fluor® 488 Anti-Lamin A/C antibody
Antigen Peptide	KLH conjugated synthetic peptide crb1200292e
Protein ID	UnitProtKB - Q8N519
Cross-Reactivity	Human
Host Species	Anti-Rabbit
Antibody Type	Polyclonal
Label	Labelled with Alexa Fluor® 488 under optimal conditions. Ex: 495nm Em:519nm
Concentration	0.57mg/ml
Validation	ELISA
Target	Lamin A/C
Disease Area	Limb-Girdle muscular dystrophy
Family	Intermediate filament (Lamins)
Specificity	Protein
Storage	Supplied in PBS containing 0.01% sodium azide. The product should be stored undiluted and protected from prolonged exposure to light. Short term storage between 2-8°C and long term storage below -20°C
References	Cesarini, E., Mozzetta, C., Marullo, F., Gregoretti, F., Gargiulo, A., Columbaro, M., Cortesi, A., Antonelli, L., Di Pelino, S., Squarzoni, S., Palacios, D., Zippo, A., Bodega, B., Oliva, G. and Lanzuolo, C. (2015). Lamin A/C sustains PcG protein architecture, maintaining transcriptional repression at target genes. J Cell Biol, 211(3), 533-551. PMID:26553927 Gruenbaum, Y. and Foisner, R. (2015). Lamins: Nuclear Intermediate Filament Proteins with Fundamental Functions in Nuclear Mechanics and Genome Regulation.Annu Rev Biochem, 84(1), 31-164. PMID: 25747401

Discovery Antibodies的Cyclin dependant kinase 2 (CDK2) is a serine/threonine protein kinase which controls both G1/S and G2/M transitions. CDKs along with cyclins and CDK inhibitors regulate cell cycle progression. Specific cyclins activate different CDKs; in early G1, CDK2 pairs with cyclin E to promote entry into the S phase before switching to partner with cyclin A to drive the cell through S phase. Once activated CDKs phosphorylate downstream proteins to initiate signalling cascades. CDK2 phosphorylates and inactivates the RB1 (pRb) tumour suppressor family of proteins.CDK的活动受到严格控制。CDK2活性可以被包括P21在内的一系列抑制剂抑制。细胞周期失调和增殖控制的丧失与细胞转化和癌症密切相关。CDK2在DNA损伤反应（DDR）中的细胞周期停滞中也似乎起着积极作用，它的抑制作用会阻碍DDR，并使细胞对电离辐射敏感，从而诱导细胞死亡。该抗体与AlexaFluor®488偶联。AlexaFluor®488是一种流行的鲜绿色荧光染料，具有高pH稳定性。