Cataloguenumbercrb2005025AntibodyAnti-ERK1/2antibodyAntigenPeptideKLHconjugatedsyntheticpeptidecrb1200306eProteinIDUniProtKB-P27361AliasesExtracellularSignal-RelatedKinase1,ERK1,ERK-1,ERK2,ERK-2,Mitogen-ActivatedProteinKinase3,MAPKinase3,MAPK3.Cross-ReactivityHuman,Rat,MouseHostSpeciesAnti-RabbitAntibodyTypePolyclonalConcentration1mg/mlValidation1:1000(WB),1:1000(ELISA)TargetERK1/2FamilyMitogen-activatedprotein(MAP)kinasesfamilySpecificityERK1andERK2StorageThismaterialissuppliedinPBScontaining0.01%sodiumazideand1%trehalose.Theproductshouldbestoredat+4°Cforshorttermstorageand-20°Cforlongtermstorage.Avoidrepeatedfreeze/thawcycles.References

Cook,S.,Stuart,K.,Gilley,R.andSale,M.(2017).ControlofcelldeathandmitochondrialfissionbyERK1/2MAPkinasesignalling.FEBSJ,284(24),4177-4195.PMID:28548464

Zou,J.,Lei,T.,Guo,P.,Yu,J.,Xu,Q.,Luo,Y.,Ke,R.andHuang,D.(2018).MechanismsshapingtheroleofERK1/2incellularsenescence(Review).MolMedRep,19(2),759–770.PMID:30535440

Santa_Cruz_alternativesc-93,sc-514302 Discovery Antibodies的Cyclin dependant kinase 2 (CDK2) is a serine/threonine protein kinase which controls both G1/S and G2/M transitions. CDKs along with cyclins and CDK inhibitors regulate cell cycle progression. Specific cyclins activate different CDKs; in early G1, CDK2 pairs with cyclin E to promote entry into the S phase before switching to partner with cyclin A to drive the cell through S phase. Once activated CDKs phosphorylate downstream proteins to initiate signalling cascades. CDK2 phosphorylates and inactivates the RB1 (pRb) tumour suppressor family of proteins.CDK的活动受到严格控制。CDK2活性可以被包括P21在内的一系列抑制剂抑制。细胞周期失调和增殖控制的丧失与细胞转化和癌症密切相关。CDK2在DNA损伤反应（DDR）中的细胞周期停滞中也似乎起着积极作用，它的抑制作用会阻碍DDR，并使细胞对电离辐射敏感，从而诱导细胞死亡。该抗体与AlexaFluor®488偶联。AlexaFluor®488是一种流行的鲜绿色荧光染料，具有高pH稳定性。