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蚂蚁淘在线 / 品牌中心 / Discovery / Discovery Antibodies/Amitriptyline hydrochloride/10 g/A-155-10 g

Discovery Antibodies/Amitriptyline hydrochloride/10 g/A-155-10 g

价格

￥600.00

货号：A-155-10g

浏览量：127

品牌：Discovery

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商品描述

Cat#:A-155

AlternativeNameAnnoyltin^®,Tryptizol^®,Domical^®,Elavilhydrochloride^®,Amavil^®,Saroten^®,Ami-Anelun^®,Lentizol^®

LyophilizedPowder

BioassayTested

SourceSynthetic

MW:313.86

Purity:>99%

Effectiveconcentration1-100µM.

Structure-+

Chemicalname3-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-1-propanaminehydrochloride.

MolecularformulaC₂₀H₂₄ClN.

CASNo.:549-18-8.

ActivityInhibitorofSEROtoninandnoradrenalinuptake.Alsoactivatesα2A-adrenoceptorsandantagonizes5-HT2receptors.Displaysantinociceptiveactivity¹.

References-Activity-+

ShippingandstorageShippedatroomtemperature.Productassuppliedcanbestoredintactatroomtemperatureforseveralweeks.Forlongerperiods,itshouldbestoredat-20°C.

SolubilityDMSO.Centrifugeallproductpreparationsbeforeuse(10000xg5min).

StorageofsolutionsUptofourweeksat4°Corthreemonthsat-20°C.

Ourbioassay-+

References-Scientificbackground

1.Soldatov,N.M. (2012) ISRNMol.Biol. 2012,691341.

2.Haderer,A. etal. (2003) Anesth.Analg. 96, 1707.

3.Baldessarini,R.J. etal.(1995) ThePharmacologicalBasisofTherapeutics 431.

4.Bryson,H.M.and Wilde,M.I. (1996) DrugsAging 8, 459.

5.Zahradník,I. etal.(2008) J.Pharmacol.Exp.Ther. 324, 977.

Scientificbackground-+

TargetL-typeCa²⁺channels,α-adrenergicreceptors,5-HT2serotoninreceptors

LyophilizedPowder

Clickheretoreceivea10gfreetrialsample!

Lastupdate:22/09/2019

Amitriptylinehydrochloride(#A-155) isahighlypure,synthetic,andbiologicallyactivecompound.

Forresearchpurposesonly,notforhumanuse

Discovery Antibodies的Cyclin dependant kinase 2 (CDK2) is a serine/threonine protein kinase which controls both G1/S and G2/M transitions. CDKs along with cyclins and CDK inhibitors regulate cell cycle progression. Specific cyclins activate different CDKs; in early G1, CDK2 pairs with cyclin E to promote entry into the S phase before switching to partner with cyclin A to drive the cell through S phase. Once activated CDKs phosphorylate downstream proteins to initiate signalling cascades. CDK2 phosphorylates and inactivates the RB1 (pRb) tumour suppressor family of proteins.CDK的活动受到严格控制。CDK2活性可以被包括P21在内的一系列抑制剂抑制。细胞周期失调和增殖控制的丧失与细胞转化和癌症密切相关。CDK2在DNA损伤反应（DDR）中的细胞周期停滞中也似乎起着积极作用，它的抑制作用会阻碍DDR，并使细胞对电离辐射敏感，从而诱导细胞死亡。该抗体与AlexaFluor®488偶联。AlexaFluor®488是一种流行的鲜绿色荧光染料，具有高pH稳定性。

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