Catalogue numbercrb2005216AntibodyAnti-p53 antibodyAntigen PeptideKLH conjugated synthetic peptide crb1200508eProtein IDUniProtKB - P04637Aliasestumour protein p53, cellular tumour antigen p53, phosphoprotein p53, tumour suppressor p53, antigen NY-CO-13, transformation-related protein 53 (TRP53)Cross-ReactivityHumanHost Species RabbitAntibody TypePolyclonalConcentration0.1 mg/mlValidation1:1000 (ELISA), 1:1000 (WB)Targetp53Disease AreaCancer, DNA Damage, apoptosis, transcription, cell cycle, signal transductionSpecificityProteinStorage This material is supplied in PBS containing 0.01% sodium azide and 1% trehalose. The product should be stored at +4°C for short term storage and -20°C for long term storage. Avoid repeated freeze/ thaw cycles. References

Cheok, C. and Lane, D. (2017). Exploiting the p53 Pathway for Therapy. Cold Spring Harb Perspect Med, 7(3), a026310. PMID: 28193768

Kastenhuber, E. and Lowe, S. (2017). Putting p53 in Context. Cell, 170(6), 1062-1078. PMID: 28886379

Discovery Antibodies的Cyclin dependant kinase 2 (CDK2) is a serine/threonine protein kinase which controls both G1/S and G2/M transitions. CDKs along with cyclins and CDK inhibitors regulate cell cycle progression. Specific cyclins activate different CDKs; in early G1, CDK2 pairs with cyclin E to promote entry into the S phase before switching to partner with cyclin A to drive the cell through S phase. Once activated CDKs phosphorylate downstream proteins to initiate signalling cascades. CDK2 phosphorylates and inactivates the RB1 (pRb) tumour suppressor family of proteins.CDK的活动受到严格控制。CDK2活性可以被包括P21在内的一系列抑制剂抑制。细胞周期失调和增殖控制的丧失与细胞转化和癌症密切相关。CDK2在DNA损伤反应（DDR）中的细胞周期停滞中也似乎起着积极作用，它的抑制作用会阻碍DDR，并使细胞对电离辐射敏感，从而诱导细胞死亡。该抗体与AlexaFluor®488偶联。AlexaFluor®488是一种流行的鲜绿色荧光染料，具有高pH稳定性。