Cataloguenumbercrb2005000AntibodyAnti-β-actinantibodyAntigenPeptideKLHconjugatedsyntheticpeptidecrb1200274eProteinIDUniProtKB-P60709AliasesACTB,BRWS1,PS1TP5BP1,Beta-actin,βactin,β-actin,βactinCross-ReactivityHuman,Rat,MouseHostSpeciesRabbitAntibodyTypePolyclonalLabelUnconjugatedConcentration1mg/mlValidationWB/ELISATargetβ-actinDiseaseAreaCellmotility,structureandintegrityFamilyActinSuperFamilyInternalcellularproteinSpecificityProteinPost-translationalModificationNoneStorageThismaterialissuppliedinPBScontaining0.01%sodiumazideand1%trehalose.Theproductshouldbestoredat+4°Cforshorttermstorageand-20°Cforlongtermstorage.Avoidrepeatedfreeze/thawcycles.References

Dugina,V.,Khromova,N.,Rybko,V.,Blizniukov,O.,Shagieva,G.,Chaponnier,C.,Kopnin,B.andKopnin,P.(2015).Tumorpromotionbyγandsuppressionbyβnon-muscleactinisoforms.Oncotarget,6(16).PMID:26008973

Discovery Antibodies的Cyclin dependant kinase 2 (CDK2) is a serine/threonine protein kinase which controls both G1/S and G2/M transitions. CDKs along with cyclins and CDK inhibitors regulate cell cycle progression. Specific cyclins activate different CDKs; in early G1, CDK2 pairs with cyclin E to promote entry into the S phase before switching to partner with cyclin A to drive the cell through S phase. Once activated CDKs phosphorylate downstream proteins to initiate signalling cascades. CDK2 phosphorylates and inactivates the RB1 (pRb) tumour suppressor family of proteins.CDK的活动受到严格控制。CDK2活性可以被包括P21在内的一系列抑制剂抑制。细胞周期失调和增殖控制的丧失与细胞转化和癌症密切相关。CDK2在DNA损伤反应（DDR）中的细胞周期停滞中也似乎起着积极作用，它的抑制作用会阻碍DDR，并使细胞对电离辐射敏感，从而诱导细胞死亡。该抗体与AlexaFluor®488偶联。AlexaFluor®488是一种流行的鲜绿色荧光染料，具有高pH稳定性。