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蚂蚁淘在线 / 品牌中心 / Discovery / Discovery Antibodies/Anti-Aquaporin 4 (AQP4) (300-314)-ATTO-594 Antibody/50 µl/AQP-014-AR-50 µl

Discovery Antibodies/Anti-Aquaporin 4 (AQP4) (300-314)-ATTO-594 Antibody/50 µl/AQP-014-AR-50 µl

价格

￥10540.00

货号：AQP-014-AR-50µl

浏览量：97

品牌：Discovery

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商品描述

Cat#:AQP-014-AR

AlternativeNameWCH4,Mercurial-insensitivewaterchannel

LyophilizedPowder

AntigenIncl.

Type:Polyclonal

Host:Rabbit

Reactivity:m,r

Mayalsoworkin:h*

Immunogen-+

Accession(Uniprot)NumberP47863

GeneID25293

PeptideconfirmationConfirmedbyaminoacidanalysisandmassspectrometry.

HomologyMouse-14/15aminoacidresiduesidentical;human-13/15aminoacidresiduesidentical.

RRIDAB_2756786.

PurityAffinitypurifiedonimmobilizedantigen.

FormLyophilizedpowder.Reconstitutedantibodycontainsphosphatebufferedsaline(PBS),pH7.4,1%BSA,0.05%NaN₃.

IsotypeRabbitIgG.

LabelATTO-594.Maximumabsorption601nm;Maximumfluorescence627nm.Thefluorescenceisexcitedmostefficientlyinthe580–615nmrange.ThislabelbelongstotheclassofRhodaminedyesandcanbeusedwithfluorescentequipmenttypicallyoptimizedtodetectTexasRedandAlexa-594.

StoragebeforereconstitutionTheantibodyshipsasalyophilizedpowderatroomtemperature.Uponarrival,itshouldbestoredat-20°C.

Reconstitution50µldoubledistilledwater(DDW).

Antibodyconcentrationafterreconstitution1mg/ml.

StorageafterreconstitutionThereconstitutedsolutioncanbestoredat4°C,protectedfromthelight,forupto1week.Forlongerperiods,smallaliquotsshouldbestoredat-20°C.Avoidmultiplefreezingandthawing.Centrifugeallantibodypreparationsbeforeuse(10000×g5min).

NegativecontrolantigenstoragebeforereconstitutionLyophilizedpowdercanbestoredintactatroomtemperaturefor2weeks.Forlongerperiods,itshouldbestoredat-20°C.

Negativecontrolantigenreconstitution100µldoubledistilledwater(DDW).

Negativecontrolantigenstorageafterreconstitution-20°C.

PreadsorptionControl1µgpeptideper1µgantibody.

StandardqualitycontrolofeachlotWesternblotanalysis(unlabeledantibody,#AQP-014),andimmunohistochemicalstaining(labeledantibody).

Applications:if,ih

Mayalsoworkin:ic*

Immunohistochemistry-+

References

1.King,L.S.etal.(2004)Nat.Rev.Mol.CellBiol.5,687.

2.Manley,G.T.etal.(2004)Neuroscience.129,983.

3.Lennon,V.A.etal.(2005)J.Exp.Med.202,473.

Scientificbackground-+

LyophilizedPowderNegativeControlAntigenIncluded

Image&Title: Anti-Aquaporin 4 (AQP4) (300-314)-ATTO-594 Antibody

Immuno-colocalizationofAquaporin4andTrkBinratcerebellum.Immunohistochemicalstainingofperfusion-fixedfrozenratcerebellumsectionsusingAnti-TrkB(extracellular)-ATTO-488Antibody(#ANT-019-AG),(1:80)andAnti-Aquaporin4(AQP4)(300-314)-ATTO-594Antibody(#AQP-014-AR),(1:80).A.TrkBlabeling(green)appearsinPurkinjecells(arrows)formingthePurkinjelayer(P).B.Aquaporin4staining(red)appearsinoutlinesofthe“baskets”formedaroundPurkinjecells(verticalarrows)andinsomebloodvessels(horizontalarrow).C.MergeofpanelsAandBdemonstratesthelocalizationofTrkBandAquaporin4inadjacentcellularcompartmentsofthecerebellum.NucleiweredemonstratedusingDAPIasthecounterstain(blue).

Lastupdate:21/11/2019

Anti-Aquaporin4(AQP4)(300-314)Antibody (#AQP-014)isahighlyspecificantibodydirectedagainstanepitopeofratAQP4.Theantibodycanbeusedinwesternblot,immunohistochemistry,andimmunocytochemistryapplications.IthasbeendesignedtorecognizetheAquaporin4channelfromrat,mouse,andhumansamples.

Anti-Aquaporin4(AQP4)(300-314)-ATTO-594Antibody(#AQP-014-AR) isdirectlylabeledwithanATTO-594fluorescentdye. ATTOdyes arecharacterizedbystrongabsorption(highextinctioncoefficient),highfluorescencequantumyield,andhighphoto-stability.TheATTO-594fluorescentlabelbelongstotheclassofRhodaminedyesandcanbeusedwithfluorescentequipmenttypicallyoptimizedtodetectTexasRedandAlexa-594.Anti-Aquaporin4(AQP4)(300-314)-ATTO-594AntibodyisespeciallysuitedforexperimentsrequiringsimultaneouslabelingofdifferentMarkers.

Forresearchpurposesonly,notforhumanuse

Discovery Antibodies的Cyclin dependant kinase 2 (CDK2) is a serine/threonine protein kinase which controls both G1/S and G2/M transitions. CDKs along with cyclins and CDK inhibitors regulate cell cycle progression. Specific cyclins activate different CDKs; in early G1, CDK2 pairs with cyclin E to promote entry into the S phase before switching to partner with cyclin A to drive the cell through S phase. Once activated CDKs phosphorylate downstream proteins to initiate signalling cascades. CDK2 phosphorylates and inactivates the RB1 (pRb) tumour suppressor family of proteins.CDK的活动受到严格控制。CDK2活性可以被包括P21在内的一系列抑制剂抑制。细胞周期失调和增殖控制的丧失与细胞转化和癌症密切相关。CDK2在DNA损伤反应（DDR）中的细胞周期停滞中也似乎起着积极作用，它的抑制作用会阻碍DDR，并使细胞对电离辐射敏感，从而诱导细胞死亡。该抗体与AlexaFluor®488偶联。AlexaFluor®488是一种流行的鲜绿色荧光染料，具有高pH稳定性。

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Discovery Antibodies/Anti-Aquaporin 4 (AQP4) (300-314)-ATTO-594 Antibody/50 µl/AQP-014-AR-50 µl

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