Catalogue numbercrb2005186AntibodyAnti-Histone H3 (G34V) antibodyAntigen PeptideKLH conjugated synthetic peptide crb1200377eProtein IDUniProtKB - P84243AliasesH3 Histone Family Member 3A, H3 Histone, H3.3A H3F3, Histone H3.3, H3F3ACross-ReactivityHuman, Rabbit, MouseHost Species RabbitAntibody TypePolyclonalConcentration1mg/mlValidation1:1000 (WB), 1:1000 (ELISA), IF, IHCTargetHistone H3 (H3.3)Disease AreaHistones, TumourigenesisFamilyHistonesSpecificityProteinStorage This material is supplied in PBS containing 0.01% sodium azide and 1% trehalose. The product should be stored at +4°C for short term storage and -20°C for long term storage. Avoid repeated freeze/ thaw cycles. CitationsHaque et al. (2017) Acta Neuropathol Commun.5(1):45. PMID: 28587626References

Voon, H., Udugama, M., Lin, W., Hii, L., Law, R., Steer, D., Das, P., Mann, J. and Wong, L. (2018). Inhibition of a K9/K36 demethylase by an H3.3 point mutation found in paediatric glioblastoma. Nature Commun, 9(1). PMID: 30087349

Wu, G., Broniscer, A., McEachron, T., Lu, C., Paugh, B., Becksfort, J., Qu, C., Ding, L., Huether, R., Parker, M., Zhang, J., Gajjar, A., Dyer, M., Mullighan, C., Gilbertson, R., Mardis, E., Wilson, R., Downing, J., Ellison, D., Zhang, J. and Baker, S. (2012). Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas. Nature Genet, 44(3), 251-253. PMID: 22286216

Discovery Antibodies的Cyclin dependant kinase 2 (CDK2) is a serine/threonine protein kinase which controls both G1/S and G2/M transitions. CDKs along with cyclins and CDK inhibitors regulate cell cycle progression. Specific cyclins activate different CDKs; in early G1, CDK2 pairs with cyclin E to promote entry into the S phase before switching to partner with cyclin A to drive the cell through S phase. Once activated CDKs phosphorylate downstream proteins to initiate signalling cascades. CDK2 phosphorylates and inactivates the RB1 (pRb) tumour suppressor family of proteins.CDK的活动受到严格控制。CDK2活性可以被包括P21在内的一系列抑制剂抑制。细胞周期失调和增殖控制的丧失与细胞转化和癌症密切相关。CDK2在DNA损伤反应（DDR）中的细胞周期停滞中也似乎起着积极作用，它的抑制作用会阻碍DDR，并使细胞对电离辐射敏感，从而诱导细胞死亡。该抗体与AlexaFluor®488偶联。AlexaFluor®488是一种流行的鲜绿色荧光染料，具有高pH稳定性。