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蚂蚁淘在线 / 品牌中心 / Discovery / Discovery Antibodies/Anti-KV1.3 (KCNA3) (extracellular)-PE Antibody/2 x 50 µl/APC-101-PE-2 x 50 µl

Discovery Antibodies/Anti-KV1.3 (KCNA3) (extracellular)-PE Antibody/2 x 50 µl/APC-101-PE-2 x 50 µl

价格
￥14740.00
货号：APC-101-PE-2x50µl
浏览量：105
品牌：Discovery
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商品描述
Cat#:APC-101-PE
AlternativeNamePotassiumvoltage-gatedchannelsubfamilyAmember3
  • LyophilizedPowder
    • Type:Polyclonal
    Host:Rabbit
    Reactivity:h,m,r
      • PeptideKDYPASTSQDSFEA(C),correspondingtoaminoacidresidues263-276ofhumanKV1.3(AccessionP22001).1stextracellularloop.
        Anti-KV1.3 (KCNA3) (extracellular)-PE Antibody
    Accession(Uniprot)NumberP22001
    GeneID3738
    PeptideconfirmationConfirmedbyaminoacidanalysisandmassspectrometry.
    HomologyRat,mouse–12/14aminoacidresiduesidentical.
    PurityAffinitypurifiedonimmobilizedantigen.
    FormLyophilizedpowder.Reconstitutedantibodycontainsphosphatebufferedsaline(PBS),pH7.4,1%BSA,0.05%NaN3.
    IsotypeRabbitIgG.
    LabelR-Phycoerythrin(R-PE).
    StoragebeforereconstitutionTheantibodyshipsasalyophilizedpowderatroomtemperature.Uponarrival,itshouldbestoredat-20°C.
    Reconstitution50µldoubledistilledwater(DDW).
    Antibodyconcentrationafterreconstitution1mg/ml.
    StorageafterreconstitutionThereconstitutedsolutioncanbestoredat4°C,protectedfromthelight,forupto1week.Forlongerperiods,smallaliquotsshouldbestoredat-20°C.Avoidmultiplefreezingandthawing.Centrifugeallantibodypreparationsbeforeuse(10000×g5min).
    StandardqualitycontrolofeachlotWesternblotanalysis(unlabeledantibody,#APC-101),anddirectflowcytometry(labeledantibody).
    Applications:fc
    Mayalsoworkin:ic*,lci*
      • Anti-KV1.3 (KCNA3) (extracellular)-PE Antibody
        CellsurfacedetectionofKV1.3inhumanJurkatT-cellleukemiacells:
        ___ Cells.
        ___ Cells+rabbitIgGisotypecontrol-PE.
        ___ Cells+ Anti-KV1.3(KCNA3)(extracellular)-PEAntibody(#APC-101-PE),(5µg).
        Anti-KV1.3 (KCNA3) (extracellular)-PE Antibody
        CellsurfacedetectionofKV1.3inmouseTK-1T-celllymphomacells:
        ___ Cells.
        ___ Cells+rabbitIgGisotypecontrol-PE.
        ___ Cells+ Anti-KV1.3(KCNA3)(extracellular)-PEAntibody(#APC-101-PE),(5µg).
    References
    • 1.Chandy,K.G. etal. (2001) Toxicon 39, 1269.
    • 2.Koo,G.C. etal. (1997) J.Immunol. 158, 5120.
    • 3.Grissmer,S. etal. (1994) Mol.Pharmacol. 45, 1227.
    • 4.Garcia-Calvo,M. etal. (1993) J.Biol.Chem. 268, 18866.
    • 5.Garcia,M.L. etal. (1994) Biochemistry 33, 6834.
    • 6.Koschak,A. etal. (1998) J.Biol.Chem. 273, 2639.
    • 7.Kalman,K. etal. (1998) J.Biol.Chem. 273, 32697.

      • KV1.3 belongstothe Shaker familyof voltage-dependentK+ channels.Thechannel,encodedby KCNA3,iswidelyexpressedinthebrain,lungandosteoclastsandinseveralcell populationsofhematopoieticorigin.TheprominenceofKV1.3channelsinthesecells(particularlyinTlymphocytes)directedmuchresearch attention.ItwasfoundthatKV1.3isthemainchannelresponsIBLeformaintainingtherestingpotentialinquiescentcellsandregulatingthe Ca2+ signalingthatisindispensablefornormalTlymphocyteactivation.1,2 BasedonthecentralroleofKV1.3inregulatingtheinitiationofanimmuneresponse, thechannelhasbeenrecognizedasapotentialtargetforimmunosuppressantdrugs.1

        KV1.3channelsarepotentlyinhibitedbyseveralvenomouspeptidetoxinsamongthem CharyBDotoxin (2.6nM), Noxiustoxin (1nM), Kaliotoxin (0.65nM), Margatoxin (0.05nM), Agitoxin-1 (1.7nM), Agitoxin-2 (0.004nM), Hongotoxin-1 (0.09nM)and Stichodactylatoxin (0.01nM).3-7

        ThecentralroleofKV1.3inimmunesystemcellscreatedarealneedforaspecific antibodythatwouldbeabletoworkinflowcytometryapplications.

    Applicationkey:

    CBE-Cell-basedELISA,FC-Flowcytometry,ICC-Immunocytochemistry,IE-IndirectELISA,IF-Immunofluorescence,IFC-Indirectflowcytometry,IHC-Immunohistochemistry,IP-Immunoprecipitation,LCI-Livecellimaging,N-Neutralization,WB-Westernblot

    Speciesreactivitykey:

    H-Human,M-Mouse,R-Rat
    LyophilizedPowder
    Lastupdate:27/11/2019

    Anti-KV1.3(KCNA3)(extracellular)Antibody (#APC-101)isahighlyspecificantibodydirectedagainstanextracellularepitopeofthehumanprotein.Theantibody canbeusedinwesternblot,immunohistochemistry,livecellimagingandindirectflowcytometryapplications.IthasbeendesignedtorecognizeKV1.3potassiumchannelfromhuman,mouseandratsamples.

    Anti-KV1.3(KCNA3)(extracellular)-PEAntibody (#APC-101-PE)isdirectlyconjugatedtoPhycoerythrin(PE).Thislabeledantibody canbeusedinimmunofluorescentapplicationssuchasdirectflowcytometryandlivecellimaging.

    Forresearchpurposesonly,notforhumanuse
    Discovery Antibodies的Cyclin dependant kinase 2 (CDK2) is a serine/threonine protein kinase which controls both G1/S and G2/M transitions. CDKs along with cyclins and CDK inhibitors regulate cell cycle progression. Specific cyclins activate different CDKs; in early G1, CDK2 pairs with cyclin E to promote entry into the S phase before switching to partner with cyclin A to drive the cell through S phase. Once activated CDKs phosphorylate downstream proteins to initiate signalling cascades. CDK2 phosphorylates and inactivates the RB1 (pRb) tumour suppressor family of proteins.CDK的活动受到严格控制。CDK2活性可以被包括P21在内的一系列抑制剂抑制。细胞周期失调和增殖控制的丧失与细胞转化和癌症密切相关。CDK2在DNA损伤反应（DDR）中的细胞周期停滞中也似乎起着积极作用，它的抑制作用会阻碍DDR，并使细胞对电离辐射敏感，从而诱导细胞死亡。该抗体与AlexaFluor®488偶联。AlexaFluor®488是一种流行的鲜绿色荧光染料，具有高pH稳定性。

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