Catalogue numbercrb2005088AntibodyAnti-JAK2 antibodyAntigen PeptideKLH conjugated synthetic peptide crb1200012eProtein IDUniProtKB - O60674AliasesTyrosine-protein kinase JAK2, JAK-2, Janus kinase 2Cross-ReactivityHumanHost Species RabbitAntibody TypePolyclonalConcentration1mg/mlValidation1:500 (WB), 1:1000 (ELISA)TargetJAK2Disease AreaSignal transductionFamilyTyrosine Protein Kinase familySuper FamilyJanus KinaseSpecificityProteinStorage This material is supplied in PBS containing 0.01% sodium azide and 1% trehalose. The product should be stored at +4°C for short term storage and -20°C for long term storage. Avoid repeated freeze/ thaw cycles. References

Jay, J., Hammer, A., Nestor-Kalinoski, A. and Diakonova, M. (2014). JAK2 Tyrosine Kinase Phosphorylates and Is Negatively Regulated by Centrosomal Protein Ninein. Mol Cell Biol, 35(1), 111-131. PMID:25332239

Liu, C., Yang-Yen, H., Suen, C., Hwang, M. and Yen, J. (2017). Cbl-mediated K63-linked ubiquitination of JAK2 enhances JAK2 phosphorylation and signal transduction. Sci Rep, 7(1). PMID: 28676638

Trivedi, S. and Starz-Gaiano, M. (2018). Drosophila Jak/STAT Signaling: Regulation and Relevance in Human Cancer and Metastasis. Int J Mol Sci, 19(12), 4056. PMID: 30558204

Discovery Antibodies的Cyclin dependant kinase 2 (CDK2) is a serine/threonine protein kinase which controls both G1/S and G2/M transitions. CDKs along with cyclins and CDK inhibitors regulate cell cycle progression. Specific cyclins activate different CDKs; in early G1, CDK2 pairs with cyclin E to promote entry into the S phase before switching to partner with cyclin A to drive the cell through S phase. Once activated CDKs phosphorylate downstream proteins to initiate signalling cascades. CDK2 phosphorylates and inactivates the RB1 (pRb) tumour suppressor family of proteins.CDK的活动受到严格控制。CDK2活性可以被包括P21在内的一系列抑制剂抑制。细胞周期失调和增殖控制的丧失与细胞转化和癌症密切相关。CDK2在DNA损伤反应（DDR）中的细胞周期停滞中也似乎起着积极作用，它的抑制作用会阻碍DDR，并使细胞对电离辐射敏感，从而诱导细胞死亡。该抗体与AlexaFluor®488偶联。AlexaFluor®488是一种流行的鲜绿色荧光染料，具有高pH稳定性。