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蚂蚁淘在线 / 品牌中心 / Discovery / Discovery Antibodies/Talipexole dihydrochloride/50 mg/B-140-50 mg

Discovery Antibodies/Talipexole dihydrochloride/50 mg/B-140-50 mg

价格

￥5260.00

货号：B-140-50mg

浏览量：65

品牌：Discovery

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商品描述

Cat#:B-140

AlternativeNameB-HT920

LyophilizedPowder

BioassayTested

SourceSynthetic

MW:282.23

Purity:>98%

Effectiveconcentration0.3-300nM.

Structure-+

Chemicalname6-prop-2-enyl-4,5,7,8-tetrahydro-[1,3]thiazolo[4,5-d]azepin-2-amine;dihydrochloride.

MolecularformulaC₁₀H₁₅N₃S•2HCl.

CASNo.:36085-73-1.

ActivityB-HT920isablockerof5-HT3channels¹.ItisalsoanagoNISTofD₂dopaminereceptorsandα₂-adrenoceptors.

References-Activity-+

ShippingandstorageShippedatroomtemperature.Productassuppliedcanbestoredintactatroomtemperatureforseveralweeks.Forlongerperiods,itshouldbestoredat-20°C.

Solubility100mMinH₂O.Centrifugeallproductpreparationsbeforeuse(10000xg5min).

StorageofsolutionsUptofourweeksat4°Corthreemonthsat-20°C.

Ourbioassay-+

References-Scientificbackground

1.Nishio,H. etal. (1996) Gen.Pharmacol. 27, 779.

2.Clarke,P.B. etal. (1990) Br.J.Pharmacol. 99, 509.

3.Plosker,G.L.andBenfield,P. (1997) CNSDrugs 7, 410.

4.Inoue,Y. etal. (1999) PsychiatryClin.Neurosci. 53, 283.

Scientificbackground-+

Target5-HT3,D₂ dopamine,α₂-adrenoceptorreceptors

LyophilizedPowder

Clickheretoreceivea5mgfreetrialsample!

Lastupdate:02/09/2019

Talipexoledihydrochloride(#B-140) isahighlypure,synthetic,andbiologicallyactivecompound.

Forresearchpurposesonly,notforhumanuse

Discovery Antibodies的Cyclin dependant kinase 2 (CDK2) is a serine/threonine protein kinase which controls both G1/S and G2/M transitions. CDKs along with cyclins and CDK inhibitors regulate cell cycle progression. Specific cyclins activate different CDKs; in early G1, CDK2 pairs with cyclin E to promote entry into the S phase before switching to partner with cyclin A to drive the cell through S phase. Once activated CDKs phosphorylate downstream proteins to initiate signalling cascades. CDK2 phosphorylates and inactivates the RB1 (pRb) tumour suppressor family of proteins.CDK的活动受到严格控制。CDK2活性可以被包括P21在内的一系列抑制剂抑制。细胞周期失调和增殖控制的丧失与细胞转化和癌症密切相关。CDK2在DNA损伤反应（DDR）中的细胞周期停滞中也似乎起着积极作用，它的抑制作用会阻碍DDR，并使细胞对电离辐射敏感，从而诱导细胞死亡。该抗体与AlexaFluor®488偶联。AlexaFluor®488是一种流行的鲜绿色荧光染料，具有高pH稳定性。

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