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蚂蚁淘在线 / 品牌中心 / Discovery / Discovery Antibodies/Anti-P2Y2 Receptor (extracellular)-FITC Antibody/10 x 50 µl/APR-102-F-10 x 50 µl

Discovery Antibodies/Anti-P2Y2 Receptor (extracellular)-FITC Antibody/10 x 50 µl/APR-102-F-10 x 50 µl

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￥35940.00

货号：APR-102-F-10x50µl

浏览量：99

品牌：Discovery

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商品描述

Cat#:APR-102-F

AlternativeNameP2Ypurinoceptor2,P2RY2,P2U1

LyophilizedPowder

Type:Polyclonal

Host:Rabbit

Reactivity:h,m,r

Immunogen-+

Accession(Uniprot)NumberP41232

GeneID29597

PeptideconfirmationConfirmedbyaminoacidanalysisandmassspectrometry.

HomologyRat,mouse–14/15aminoacidresiduesidentical;human–13/15aminoacidresiduesidentical.

RRIDAB_2756770.

PurityAffinitypurifiedonimmobilizedantigen.

FormLyophilizedpowder.Reconstitutedantibodycontainsphosphatebufferedsaline(PBS),pH7.4,1%BSA,0.05%NaN₃.

IsotypeRabbitIgG.

LabelFluoresceinisothiocyanate(FITC).

StoragebeforereconstitutionTheantibodyshipsasalyophilizedpowderatroomtemperature.Uponarrival,itshouldbestoredat-20°C.

Reconstitution50µldoubledistilledwater(DDW).

Antibodyconcentrationafterreconstitution1mg/ml.

StorageafterreconstitutionThereconstitutedsolutioncanbestoredat4°C,protectedfromthelight,forupto1week.Forlongerperiods,smallaliquotsshouldbestoredat-20°C.Avoidmultiplefreezingandthawing.Centrifugeallantibodypreparationsbeforeuse(10000×g5min).

StandardqualitycontrolofeachlotWesternblotanalysis(unlabeledantibody,#APR-102),anddirectflowcytometry(labeledantibody).

Applications:fc

Mayalsoworkin:ic*,lci*

Directflowcytometry-+

References

1.Wang,L.etal.(2002)J.Cardiovas.Pharmacol.40,841.

2.Queiroz,G.etal.(2003)J.Pharmacol.Exp.Ther.307,809.

3.Ralevic,V.andBurnstock,G.(1998)Pharmacol.Rev.50,413.

4.Abbracchio,M.P.etal.(2003)TrendsPharmacol.Sci.24,52.

5.DiVirgilio,F.etal.(2001)Blood97,587.

6.Yerxa,B.R.etal.(2002)J.Pharmacol.Exp.Ther.302,871.

Scientificbackground-+

LyophilizedPowder

Lastupdate:25/12/2019

Anti-P2Y2Receptor(extracellular)Antibody (#APR-102)isahighlyspecificantibodydirectedagainstanepitopeoftheratprotein.Theantibodycanbeusedinwesternblot,indirectlivecellflowcytometry,andimmunohistochemistryapplications.IthasbeendesignedtorecognizeP2RY2fromrat,mouse,andhumansamples.

Anti-P2Y2Receptor(extracellular)–FITCAntibody (#APR-102-F)isdirectlyconjugatedtofluoresceinisothiocyanate(FITC).Thislabeledantibody canbeusedinimmunofluorescentapplicationssuchasdirectflowcytometryusinglivecells.

Forresearchpurposesonly,notforhumanuse

Discovery Antibodies的Cyclin dependant kinase 2 (CDK2) is a serine/threonine protein kinase which controls both G1/S and G2/M transitions. CDKs along with cyclins and CDK inhibitors regulate cell cycle progression. Specific cyclins activate different CDKs; in early G1, CDK2 pairs with cyclin E to promote entry into the S phase before switching to partner with cyclin A to drive the cell through S phase. Once activated CDKs phosphorylate downstream proteins to initiate signalling cascades. CDK2 phosphorylates and inactivates the RB1 (pRb) tumour suppressor family of proteins.CDK的活动受到严格控制。CDK2活性可以被包括P21在内的一系列抑制剂抑制。细胞周期失调和增殖控制的丧失与细胞转化和癌症密切相关。CDK2在DNA损伤反应（DDR）中的细胞周期停滞中也似乎起着积极作用，它的抑制作用会阻碍DDR，并使细胞对电离辐射敏感，从而诱导细胞死亡。该抗体与AlexaFluor®488偶联。AlexaFluor®488是一种流行的鲜绿色荧光染料，具有高pH稳定性。

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Discovery Antibodies/Anti-P2Y2 Receptor (extracellular)-FITC Antibody/10 x 50 µl/APR-102-F-10 x 50 µl

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