Catalogue numbercrb2005142AntibodyAnti-SOX2 antibodyAntigen PeptideKLH conjugated synthetic peptide crb1200402eProtein IDUniProtKB - P48431AliasesTranscription Factor SOX-2, Sex Determining Region Y-Box, SRY-Box Cross-ReactivityHumanHost Species RabbitAntibody TypePolyclonalConcentration0.5mg/mlValidation1:1000 (WB), 1:1000 (ELISA)TargetSOX2Super FamilySox familyStorage This material is supplied in PBS containing 0.01% sodium azide and 1% trehalose. The product should be stored at +4°C for short term storage and -20°C for long term storage. Avoid repeated freeze/ thaw cycles. References

Rothenberg, S., Concannon, K., Cullen, S., Boulay, G., Turke, A., Faber, A., Lockerman, E., Rivera, M., Engelman, J., Maheswaran, S. and Haber, D. (2015). Inhibition of mutant EGFR in lung cancer cells triggers SOX2-FOXO6-dependent survival pathways. eLife, 4. PMID: 25686219

Wuebben, E. and Rizzino, A. (2017). The dark side of SOX2: cancer - a comprehensive overview. Oncotarget, 8(27). PMID: 28388544

Discovery Antibodies的Cyclin dependant kinase 2 (CDK2) is a serine/threonine protein kinase which controls both G1/S and G2/M transitions. CDKs along with cyclins and CDK inhibitors regulate cell cycle progression. Specific cyclins activate different CDKs; in early G1, CDK2 pairs with cyclin E to promote entry into the S phase before switching to partner with cyclin A to drive the cell through S phase. Once activated CDKs phosphorylate downstream proteins to initiate signalling cascades. CDK2 phosphorylates and inactivates the RB1 (pRb) tumour suppressor family of proteins.CDK的活动受到严格控制。CDK2活性可以被包括P21在内的一系列抑制剂抑制。细胞周期失调和增殖控制的丧失与细胞转化和癌症密切相关。CDK2在DNA损伤反应（DDR）中的细胞周期停滞中也似乎起着积极作用，它的抑制作用会阻碍DDR，并使细胞对电离辐射敏感，从而诱导细胞死亡。该抗体与AlexaFluor®488偶联。AlexaFluor®488是一种流行的鲜绿色荧光染料，具有高pH稳定性。