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蚂蚁淘在线 / 品牌中心 / Discovery / Discovery Antibodies/Anti-α1B-Adrenergic Receptor (extracellular)-ATTO-488 Antibody/50 µl/AAR-018-AG-50 µl

Discovery Antibodies/Anti-α1B-Adrenergic Receptor (extracellular)-ATTO-488 Antibody/50 µl/AAR-018-AG-50 µl

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￥10540.00

货号：AAR-018-AG-50µl

浏览量：127

品牌：Discovery

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商品描述

Cat#:AAR-018-AG

AlternativeNameAlpha-1Badrenoceptor,ADA1B,ADRA1B

LyophilizedPowder

AntigenIncl.

Type:Polyclonal

Host:Rabbit

Reactivity:h,r

Immunogen-+

Accession(Uniprot)NumberP35368

GeneID147

PeptideconfirmationConfirmedbyaminoacidanalysisandmassspectrometry.

HomologyMouse-14/15aminoacidresiduesidentical;rat-13/15aminoacidresiduesidentical.

RRIDAB_2039714.

PurityAffinitypurifiedonimmobilizedantigen.

FormLyophilizedpowder.Reconstitutedantibodycontainsphosphatebufferedsaline(PBS),pH7.4,1%BSA,0.05%NaN₃.

IsotypeRabbitIgG.

LabelATTO-488.Maximumabsorption501nm;maximumfluorescence523nm.Thefluorescenceisexcitedmostefficientlyinthe480–515nmrange.Thislabelisanalogoustothewellknowndyefluoresceinisothiocyanate(FITC)andcanbeusedwithfilterstypicallyusedtodetectFITC.

StoragebeforereconstitutionTheantibodyshipsasalyophilizedpowderatroomtemperature.Uponarrival,itshouldbestoredat-20°C.

Reconstitution50µldoubledistilledwater(DDW).

Antibodyconcentrationafterreconstitution1mg/ml.

StorageafterreconstitutionThereconstitutedsolutioncanbestoredat4°C,protectedfromthelight,forupto1week.Forlongerperiods,smallaliquotsshouldbestoredat-20°C.Avoidmultiplefreezingandthawing.Centrifugeallantibodypreparationsbeforeuse(10000×g5min).

NegativecontrolantigenstoragebeforereconstitutionLyophilizedpowdercanbestoredintactatroomtemperaturefor2weeks.Forlongerperiods,itshouldbestoredat-20°C.

Negativecontrolantigenreconstitution100µldoubledistilledwater(DDW).

Negativecontrolantigenstorageafterreconstitution-20°C.

PreadsorptionControl1μgpeptideper1μgantibody.

StandardqualitycontrolofeachlotWesternblotanalysis(unlabeledantibody,#AAR-018),andlivecellimaging(labeledantibody).

Applications:fc,ic,if,lci

Mayalsoworkin:ih*

Directflowcytometry-+

Livecellimaging/Immunocytochemistry-+

References

1.IUPHARRECEPTORDATABASE|ADRENOCEPTORS

2.Piascik,M.T.andPerez,D.M.(2001)J.Pharmacol.Exp.Ther.298,403.

3.Perez,D.M.etal.(1993)Mol.Pharmacol.44,784.

4.Minneman,K.P.(1988)Pharmacol.Rev.40,87.

5.Schwinn,D.A.etal.(2004)MayoClin.Proc.79,1423.

Scientificbackground-+

LyophilizedPowderNegativeControlAntigenIncluded

Lastupdate:10/11/2019

Anti-α_1B^–AdrenergicReceptor(extracellular)Antibody(#AAR-018)isahighlyspecificantibodydirectedagainstanextracellularepitopeofthehumanα_1B-adrenoceptor.Theantibodycanbeusedinwesternblot,immunohistochemistry,livecellimagingandindirectflowcytometryapplications.Ithasbeendesignedtorecognizeα_1B-adrenoceptorfromhuman,ratandmousesamples.

Anti-α_1B-AdrenergicReceptor(extracellular)-ATTO-488Antibody(#AAR-018-AG)isdirectlylabeledwithanATTO-488fluorescentdye.ATTOdyesarecharacterizedbystrongabsorption(highextinctioncoefficient),highfluorescencequantumyield,andhighphoto-stABIlity.TheATTO-488labelisanalogoustothewellknowndyefluoresceinisothiocyanate(FITC)andcanbeusedwithfilterstypicallyusedtodetectFITC.Anti-α_1B-AdrenergicReceptor(extracellular)-ATTO-488Antibody hasbeentestedindirectflowcytometryapplicationsandisespeciallysuitedforexperimentsrequiringsimultaneouslabelingofdifferentMarkers.

Forresearchpurposesonly,notforhumanuse

Discovery Antibodies的Cyclin dependant kinase 2 (CDK2) is a serine/threonine protein kinase which controls both G1/S and G2/M transitions. CDKs along with cyclins and CDK inhibitors regulate cell cycle progression. Specific cyclins activate different CDKs; in early G1, CDK2 pairs with cyclin E to promote entry into the S phase before switching to partner with cyclin A to drive the cell through S phase. Once activated CDKs phosphorylate downstream proteins to initiate signalling cascades. CDK2 phosphorylates and inactivates the RB1 (pRb) tumour suppressor family of proteins.CDK的活动受到严格控制。CDK2活性可以被包括P21在内的一系列抑制剂抑制。细胞周期失调和增殖控制的丧失与细胞转化和癌症密切相关。CDK2在DNA损伤反应（DDR）中的细胞周期停滞中也似乎起着积极作用，它的抑制作用会阻碍DDR，并使细胞对电离辐射敏感，从而诱导细胞死亡。该抗体与AlexaFluor®488偶联。AlexaFluor®488是一种流行的鲜绿色荧光染料，具有高pH稳定性。

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Discovery Antibodies/Anti-α1B-Adrenergic Receptor (extracellular)-ATTO-488 Antibody/50 µl/AAR-018-AG-50 µl

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