Catalogue number	crb2115053e
Antibody	Alexa Fluor® 488 Anti-MRGPR-X1 antibody
Antigen Peptide	KLH conjugated synthetic peptide crb1200340e
Protein ID	UniProtKB - Q8R4G1
Cross-Reactivity	Rat, Mouse
Host Species	Anti-Rabbit
Antibody Type	Polyclonal
Concentration	0.78mg/mL
Validation	ELISA
Target	MRGPR-X1
Disease Area	Inflammatory, Neurological, Cancer
Family	MAS Related GPR Family
Specificity	Protein
Storage	Supplied in PBS containing 0.01% sodium azide. The product should be stored undiluted and protected from prolonged exposure to light. Short term storage between 2-8°C and long term storage below -20°C
References	Solinski, H., Petermann, F., Rothe, K., Boekhoff, I., Gudermann, T. and Breit, A. (2013). Human Mas-Related G Protein-Coupled Receptors-X1 Induce Chemokine Receptor 2 Expression in Rat Dorsal Root Ganglia Neurons and Release of Chemokine Ligand 2 from the Human LAD-2 Mast Cell Line. PLoS ONE, 8(3), e58756. PMID: 23505557 Solinski, H., Zierler, S., Gudermann, T. and Breit, A. (2012). Human Sensory Neuron-specific Mas-related G Protein-coupled Receptors-X1 Sensitize and Directly Activate Transient Receptor Potential Cation Channel V1 via Distinct Signaling Pathways. J Biol Chem, 287(49), 40956-40971. PMID: 23074220

Discovery Antibodies的Cyclin dependant kinase 2 (CDK2) is a serine/threonine protein kinase which controls both G1/S and G2/M transitions. CDKs along with cyclins and CDK inhibitors regulate cell cycle progression. Specific cyclins activate different CDKs; in early G1, CDK2 pairs with cyclin E to promote entry into the S phase before switching to partner with cyclin A to drive the cell through S phase. Once activated CDKs phosphorylate downstream proteins to initiate signalling cascades. CDK2 phosphorylates and inactivates the RB1 (pRb) tumour suppressor family of proteins.CDK的活动受到严格控制。CDK2活性可以被包括P21在内的一系列抑制剂抑制。细胞周期失调和增殖控制的丧失与细胞转化和癌症密切相关。CDK2在DNA损伤反应（DDR）中的细胞周期停滞中也似乎起着积极作用，它的抑制作用会阻碍DDR，并使细胞对电离辐射敏感，从而诱导细胞死亡。该抗体与AlexaFluor®488偶联。AlexaFluor®488是一种流行的鲜绿色荧光染料，具有高pH稳定性。