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蚂蚁淘在线 / 品牌中心 / Discovery / Discovery Antibodies/Anti-Human Adenosine A2A Receptor (extracellular)-FITC Antibody/50 µl/AAR-007-F-50 µl

Discovery Antibodies/Anti-Human Adenosine A2A Receptor (extracellular)-FITC Antibody/50 µl/AAR-007-F-50 µl

价格

￥10540.00

货号：AAR-007-F-50µl

浏览量：112

品牌：Discovery

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商品描述

Cat#:AAR-007-F

AlternativeNameAdenosinereceptorA_2A,A_2AR,ADORA2A

LyophilizedPowder

Type:Polyclonal

Host:Rabbit

Reactivity:h

Immunogen-+

Accession(Uniprot)NumberP29274

GeneID135

PeptideconfirmationConfirmedbyaminoacidanalysisandmassspectrometry.

HomologyHumanonly.

RRIDAB_2756537.

PurityAffinitypurifiedonimmobilizedantigen.

FormLyophilizedpowder.Reconstitutedantibodycontainsphosphatebufferedsaline(PBS),pH7.4,1%BSA,0.05%NaN₃.

IsotypeRabbitIgG.

SpecificityWillnotrecognizeratormousesamples.

LabelFluoresceinisothiocyanate(FITC).

StoragebeforereconstitutionTheantibodyshipsasalyophilizedpowderatroomtemperature.Uponarrival,itshouldbestoredat-20°C.

Reconstitution50µldoubledistilledwater(DDW).

Antibodyconcentrationafterreconstitution1mg/ml.

StorageafterreconstitutionThereconstitutedsolutioncanbestoredat4°C,protectedfromthelight,forupto1week.Forlongerperiods,smallaliquotsshouldbestoredat-20°C.Avoidmultiplefreezingandthawing.Centrifugeallantibodypreparationsbeforeuse(10000×g5min).

StandardqualitycontrolofeachlotWesternblotanalysis(unlabeledantibody,#AAR-007),anddirectflowcytometry(labeledantibody).

Applications:fc

Mayalsoworkin:ic*,lci*

Directflowcytometry-+

References

1.Okusa,M.D.(2002)Am.J.Physiol.282,F10.

2.Fredholm,B.B.etal.(2001)Pharmacol.Rev.53,527.

3.Nakata,H.(1989)J.Biol.Chem.264,16545.

4.Cunha,R.A.(2001)NeuRochem.Int.38,107.

5.Fredholm,B.B.etal.(2000)Naunyn-SchmiedebergsArch.Pharmacol.362,364.

6.Canals,M.etal.(2005)J.Neurochem.92,337.

7.Ohta,A.andSitkovsky,M.(2001)Nature414,916.

8.Ohta,A.etal.(2006)Proc.Natl.Acad.Sci.103,13132.

Scientificbackground-+

LyophilizedPowder

Lastupdate:25/09/2019

Anti-HumanAdenosineA_2A Receptor(extracellular)Antibody (#AAR-007)isahighlyspecificantibodydirectedagainstanepitopeofthehumanprotein.Theantibodycanbeusedinwesternblotandlivecellflowcytometryapplications.IthasbeendesignedtorecognizeA2aRfromhumansamplesonly.Theantibodywillnotrecognizethereceptorfrommouseorratsamples.

Anti-HumanAdenosineA_2A Receptor(extracellular)-FITC Antibody (#AAR-007-F)is directlyconjugatedtofluoresceinisothiocyanate(FITC). The antibodycanbeusedinimmunofluorescentapplicationssuchasdirectlivecellflowcytometry.

Forresearchpurposesonly,notforhumanuse

Discovery Antibodies的Cyclin dependant kinase 2 (CDK2) is a serine/threonine protein kinase which controls both G1/S and G2/M transitions. CDKs along with cyclins and CDK inhibitors regulate cell cycle progression. Specific cyclins activate different CDKs; in early G1, CDK2 pairs with cyclin E to promote entry into the S phase before switching to partner with cyclin A to drive the cell through S phase. Once activated CDKs phosphorylate downstream proteins to initiate signalling cascades. CDK2 phosphorylates and inactivates the RB1 (pRb) tumour suppressor family of proteins.CDK的活动受到严格控制。CDK2活性可以被包括P21在内的一系列抑制剂抑制。细胞周期失调和增殖控制的丧失与细胞转化和癌症密切相关。CDK2在DNA损伤反应（DDR）中的细胞周期停滞中也似乎起着积极作用，它的抑制作用会阻碍DDR，并使细胞对电离辐射敏感，从而诱导细胞死亡。该抗体与AlexaFluor®488偶联。AlexaFluor®488是一种流行的鲜绿色荧光染料，具有高pH稳定性。

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Discovery Antibodies/Anti-Human Adenosine A2A Receptor (extracellular)-FITC Antibody/50 µl/AAR-007-F-50 µl

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