Catalogue number	crb2115015e
Antibody	Alexa Fluor® 488 Anti-HAND-1 antibody
Antigen Peptide	KLH conjugated synthetic peptide crb1200298f
Protein ID	UniProtKB - O96004
Cross-Reactivity	Human, Rat, Mouse
Host Species	Anti-Sheep
Antibody Type	Polyclonal
Concentration	0.69mg/ml
Validation	ELISA
Target	HAND-1
Disease Area	Cardiovascular
Family	Basic helix-loop-helix
Specificity	Protein
Storage	Supplied in PBS containing 0.01% sodium azide. The product should be stored undiluted and protected from prolonged exposure to light. Short term storage between 2-8°C and long term storage below -20°C.
References	Barnes, R. and Firulli, A. (2009). A twist of insight - the role of Twist-family bHLH factors in development. Int J Dev Biol, 53(7), 909-924. PMID: 19378251 Firulli, B., Fuchs, R., Vincentz, J., Clouthier, D. and Firulli, A. (2014). Hand1 phosphoregulation within the distal arch neural crest is essential for craniofacial morphogenesis. Development, 141(15), 3050-3061. PMID: 25053435

Discovery Antibodies的Cyclin dependant kinase 2 (CDK2) is a serine/threonine protein kinase which controls both G1/S and G2/M transitions. CDKs along with cyclins and CDK inhibitors regulate cell cycle progression. Specific cyclins activate different CDKs; in early G1, CDK2 pairs with cyclin E to promote entry into the S phase before switching to partner with cyclin A to drive the cell through S phase. Once activated CDKs phosphorylate downstream proteins to initiate signalling cascades. CDK2 phosphorylates and inactivates the RB1 (pRb) tumour suppressor family of proteins.CDK的活动受到严格控制。CDK2活性可以被包括P21在内的一系列抑制剂抑制。细胞周期失调和增殖控制的丧失与细胞转化和癌症密切相关。CDK2在DNA损伤反应（DDR）中的细胞周期停滞中也似乎起着积极作用，它的抑制作用会阻碍DDR，并使细胞对电离辐射敏感，从而诱导细胞死亡。该抗体与AlexaFluor®488偶联。AlexaFluor®488是一种流行的鲜绿色荧光染料，具有高pH稳定性。