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蚂蚁淘在线 / 品牌中心 / Discovery / Discovery Antibodies/Anti-Calcium Sensing Receptor (extracellular) Antibody/25 µl/ACR-004-25 µl

Discovery Antibodies/Anti-Calcium Sensing Receptor (extracellular) Antibody/25 µl/ACR-004-25 µl

价格

￥4940.00

货号：ACR-004-25µl

浏览量：127

品牌：Discovery

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商品描述

Cat#:ACR-004

AlternativeNameCaSR,Extracellularcalcium-sensingreceptor,Parathyroidcellcalcium-sensingreceptor1,PCaR1,GPRC2A

LyophilizedPowder

AntigenIncl.

Type:Polyclonal

Host:Rabbit

Reactivity:h,m,r

Immunogen-+

Accession(Uniprot)NumberP41180

GeneID846

PeptideconfirmationConfirmedbyaminoacidanalysisandmassspectrometry.

HomologyRat,mouse,bovine,canis-identical.

RRIDAB_2039760.

PurityAffinitypurifiedonimmobilizedantigen.

FormLyophilizedpowder.Reconstitutedantibodycontainsphosphatebufferedsaline(PBS),pH7.4,1%BSA,0.05%NaN₃.

IsotypeRabbitIgG.

StoragebeforereconstitutionTheantibodyshipsasalyophilizedpowderatroomtemperature.Uponarrival,itshouldbestoredat-20°C.

Reconstitution25µl,50µlor0.2mldoubledistilledwater(DDW),dependingonthesamplesize.

Antibodyconcentrationafterreconstitution0.75mg/ml.

StorageafterreconstitutionThereconstitutedsolutioncanbestoredat4°Cforupto1week.Forlongerperiods,smallaliquotsshouldbestoredat-20°C.Avoidmultiplefreezingandthawing.Centrifugeallantibodypreparationsbeforeuse(10000xg5min).

NegativecontrolantigenstoragebeforereconstitutionLyophilizedpowdercanbestoredintactatroomtemperaturefor2weeks.Forlongerperiods,itshouldbestoredat-20°C.

Negativecontrolantigenreconstitution100µldoubledistilledwater(DDW).

Negativecontrolantigenstorageafterreconstitution-20°C.

PreadsorptionControl1µgpeptideper1µgantibody.

StandardqualitycontrolofeachlotWesternblotanalysis.

Applications:ic,if,ifc,ih,lci,wb

Mayalsoworkin:ip*

Westernblot-+

Immunohistochemistry-+

Indirectflowcytometry-+

Livecellimaging/Immunocytochemistry-+

References

1.IUPHARRECEPTORDATABASE.

2.Racz,G.Z.etal.(2002)Gut51,705.

3.Canaff,L.andHendy,G.N.(2002)J.Biol.Chem.277,30337.

4.Chen,R.A.andGoodman,W.G.(2004)Am.J.Physiol.RenalPhysiol.286,F1005

5.Chattopadhyay,N.(2006)Am.J.Physiol.Endocrinol.Metab.290,E761.

Scientificbackground-+

LyophilizedPowderNegativeControlAntigenIncluded

Clickheretoreceivea25µlfreetrialsample!

Lastupdate:10/11/2019

Anti-CalciumSensingReceptor(extracellular)Antibody(#ACR-004)isahighlyspecificantibodydirectedagainstanepitopeofthehumanCaSR.Theantibodycanbeusedinwesternblot,immunohistochemistry,indirectflowcytometry,andimmunocytochemistry,andlivecellimagingapplications.IthasbeendesignedtorecognizeCaSRfromhuman,rat,andmousesamples.

Forresearchpurposesonly,notforhumanuse

Discovery Antibodies的Cyclin dependant kinase 2 (CDK2) is a serine/threonine protein kinase which controls both G1/S and G2/M transitions. CDKs along with cyclins and CDK inhibitors regulate cell cycle progression. Specific cyclins activate different CDKs; in early G1, CDK2 pairs with cyclin E to promote entry into the S phase before switching to partner with cyclin A to drive the cell through S phase. Once activated CDKs phosphorylate downstream proteins to initiate signalling cascades. CDK2 phosphorylates and inactivates the RB1 (pRb) tumour suppressor family of proteins.CDK的活动受到严格控制。CDK2活性可以被包括P21在内的一系列抑制剂抑制。细胞周期失调和增殖控制的丧失与细胞转化和癌症密切相关。CDK2在DNA损伤反应（DDR）中的细胞周期停滞中也似乎起着积极作用，它的抑制作用会阻碍DDR，并使细胞对电离辐射敏感，从而诱导细胞死亡。该抗体与AlexaFluor®488偶联。AlexaFluor®488是一种流行的鲜绿色荧光染料，具有高pH稳定性。

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Discovery Antibodies/Anti-Calcium Sensing Receptor (extracellular) Antibody/25 µl/ACR-004-25 µl

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